ArticlePloS one2017
Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2019Trial
- Gulf War Illness, Fibromyalgia, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID Overlap in Common Symptoms and Underlying Biological Mechanisms: Implications for Future Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Exposure to Gulf war illness-related chemicals exacerbates alcohol-induced liver damage in rodents.Scientific reports · 2024Article
- Bioenergetic impairment in Gulf War illness assessed viaScientific reports · 2024Article
- Exposure to Gulf war illness-related chemicals exacerbates alcohol- induced liver damage in rodents.Research square · 2024Article
- Gulf war toxicant-induced effects on the hippocampal dendritic arbor are reversed by treatment with aFrontiers in neuroscience · 2024Article
- Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity.Scientific reports · 2023Article
- Chemical exposures and suspected impact on Gulf War Veterans.Military Medical Research · 2023Article
- Unexplained dyspnea linked to mitochondrial myopathy following military deployment to Southwest Asia and Afghanistan.Physiological reports · 2023Article
- Bioenergetic function is decreased in peripheral blood mononuclear cells of veterans with Gulf War Illness.PloS one · 2023Observational
- Pyridostigmine bromide, chlorpyrifos, and DEET combined Gulf War exposure insult depresses mitochondrial function in neuroblastoma cells.Journal of biochemical and molecular toxicology · 2021Article
- Gene-Toxicant Interactions in Gulf War Illness: Differential Effects of theBrain sciences · 2021Article
- Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness.Brain, behavior, and immunity · 2021Article
- Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls.Military Medical Research · 2021Observational
- Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.Pharmacology & therapeutics · 2021Review
- A Pilot Study of Bioenergetic Marker Relationships in Gulf War Illness: Phosphocreatine Recovery vs. Citric Acid Cycle Intermediates.International journal of environmental research and public health · 2021Article
- PTSD as an Endothelial Disease: Insights From COVID-19.Frontiers in cellular neuroscience · 2021Review
- Genome-wide transcriptome architecture in a mouse model of Gulf War Illness.Brain, behavior, and immunity · 2020Article
- Radiation Exposure Predicts Reported Vaccine Adverse Effects in Veterans with Gulf War Illness.International journal of environmental research and public health · 2020Article
- An analysis of 2-day cardiopulmonary exercise testing to assess unexplained fatigue.Physiological reports · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Gulf War Illness (GWI) is a chronic multi-symptom illness not currently diagnosed by standard medical or laboratory test that affects 30% of veterans who served during the 1990-1991 Gulf War. The clinical presentation of GWI is comparable to that of patients with certain mitochondrial disorders-i.e., clinically heterogeneous multisystem symptoms. Therefore, we hypothesized that mitochondrial dysfunction may contribute to both the symptoms of GWI as well as its persistence over time. We recruited 21 cases of GWI (CDC and Kansas criteria) and 7 controls to participate in this study. Peripheral blood samples were obtained in all participants and a quantitative polymerase chain reaction (QPCR) based assay was performed to quantify mitochondrial and nuclear DNA lesion frequency and mitochondrial DNA (mtDNA) copy number (mtDNAcn) from peripheral blood mononuclear cells. Samples were also used to analyze nuclear DNA lesion frequency and enzyme activity for mitochondrial complexes I and IV. Both mtDNA lesion frequency (p = 0.015, d = 1.13) and mtDNAcn (p = 0.001; d = 1.69) were elevated in veterans with GWI relative to controls. Nuclear DNA lesion frequency was also elevated in veterans with GWI (p = 0.344; d = 1.41), but did not reach statistical significance. Complex I and IV activity (p > 0.05) were similar between groups and greater mtDNA lesion frequency was associated with reduced complex I (r2 = -0.35, p = 0.007) and IV (r2 = -0.28, p < 0.01) enzyme activity. In conclusion, veterans with GWI exhibit greater mtDNA damage which is consistent with mitochondrial dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.