ArticlePloS one2017
Effect of dialyzer membrane materials on survival in chronic hemodialysis patients: Results from the annual survey of the Japanese Nationwide Dialysis Registry.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- High-flux hemodialysis with polymethylmethacrylate membranes reduces soluble CD40L, a mediator of cardiovascular disease in uremia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Trial
- Randomised trial on clinical performances and biocompatibility of four high-flux hemodialyzers in two mode treatments: hemodialysis vs post dilution hemodiafiltration.Scientific reports · 2019Trial
- Personalized Hemodialysis Approaches in Frail Older Individuals.Geriatrics (Basel, Switzerland) · 2026Review
- Membrane-to-Patient Optimization: Individualized Dialyzer Selection for Extracorporeal Dialysis.Toxins · 2026Review
- Current dialyzer classification in Japan and mortality risk in patients undergoing hemodialysis.Scientific reports · 2024Article
- Article
- Clinical effect of different dialyzers used in patients with kidney disease: a meta-analysis of randomized clinical trials.Revista da Associacao Medica Brasileira (1992) · 2023Article
- The change in Geriatric Nutritional Risk Index is associated with mortality in patients who start hemodialysis: Korean Renal Data Registry, 2016-2018.Scientific reports · 2022Article
- Super high-flux membrane dialyzers improve mortality in patients on hemodialysis: a 3-year nationwide cohort study.Clinical kidney journal · 2022Article
- Effects of Low-Flux and High-Flux Dialysis Membranes on Erythropoietin Responsiveness in Hemodialysis Patients.International journal of nephrology · 2022Article
- Dialyzer surface area is a significant predictor of mortality in patients on hemodialysis: a 3-year nationwide cohort study.Scientific reports · 2021Article
- Hemodialysis raises oxidative stress through carbon-centered radicals despite improved biocompatibility.Journal of clinical biochemistry and nutrition · 2021Article
- High-performance dialyzers and mortality in maintenance hemodialysis patients.Scientific reports · 2021Article
- Significance of Levocarnitine Treatment in Dialysis Patients.Nutrients · 2021Review
- Dialyzer Classification and Mortality in Hemodialysis Patients: A 3-Year Nationwide Cohort Study.Frontiers in medicine · 2021Article
- Arteriovenous access in hemodialysis: A multidisciplinary perspective for future solutions.The International journal of artificial organs · 2021Review
- Understanding Development of Malnutrition in Hemodialysis Patients: A Narrative Review.Nutrients · 2020Review
- The effects of dialysis modalities on the progression of coronary artery calcification in dialysis patients.BMC nephrology · 2020Article
- Molecular Mechanisms of Premature Aging in Hemodialysis: The Complex Interplay Between Innate and Adaptive Immune Dysfunction.International journal of molecular sciences · 2020Review
- MRI analysis of carpal tunnel syndrome in hemodialysis patients versus non-hemodialysis patients: a multicenter case-control study.Journal of orthopaedic surgery and research · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle information is available regarding which type of dialyzer membrane results in good prognosis in patients on chronic hemodialysis. Therefore, we conducted a cohort study from a nationwide registry of hemodialysis patients in Japan to establish the association between different dialyzer membranes and mortality rates.
methodsWe followed 142,412 patients on maintenance hemodialysis (female, 39.1%; mean age, 64.8 ± 12.3 years; median dialysis duration, 7 [4-12] years) for a year from 2008 to 2009. We included patients treated with seven types of high-flux dialyzer membranes at baseline, including cellulose triacetate (CTA), ethylene vinyl alcohol (EVAL), polyacrylonitrile (PAN), polyester polymer alloy (PEPA), polyethersulfone (PES), polymethylmethacrylate (PMMA), and polysulfone (PS). Cox regression was used to estimate the association between baseline dialyzers and all-cause mortality as hazard ratios (HRs) and 95% confidence intervals for 1-year mortality adjusting for potential confounders, and propensity score matching analysis was performed.
resultsThe distribution of patients treated with each membrane was as follows: PS (56.0%), CTA (17.3%), PES (12.0%), PEPA (7.5%), PMMA (4.9%), PAN (1.2%), and EVAL (1.1%). When data were adjusted using basic factors, with PS as a reference group, the mortality rate was significantly higher in all groups except for the PES group. When data were further adjusted for dialysis-related factors, HRs were significantly higher for the CTA, EVAL, and PEPA groups. When the data were further adjusted for nutrition-and inflammation-related factors, HRs were significantly lower for the PMMA and PES groups compared with the PS group. After propensity score matching, HRs were significantly lower for the PMMA group than for the PS group.
conclusionThe results suggest that the use of different membrane types may affect mortality in hemodialysis patients. However, further long-term prospective studies are needed to clarify these findings, including whether the use of the PMMA membrane can improve prognosis.
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