Evidence map›Paper›PMID 28910091›Full record

ArticleJournal of agricultural and food chemistry2017

Bioassay-Guided Isolation of Antioxidant and Cytoprotective Constituents from a Maqui Berry (Aristotelia chilensis) Dietary Supplement Ingredient As Markers for Qualitative and Quantitative Analysis.

Jie Li, Chunhua Yuan, Li Pan, P Annécie Benatrehina, Heebyung Chai, William J Keller, C Benjamin Naman, A Douglas Kinghorn

Abstract read
In one paragraph

Article in Journal of agricultural and food chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Rosarugosides A and D fromPlants (Basel, Switzerland) · 2024
    Article
  2. Review
  3. Article
  4. 2-International journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jie LiDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.
Chunhua YuanNuclear Magnetic Resonance Facility, Campus Chemical Instrument Center, The Ohio State University , Columbus, Ohio 43210, United States.
Li PanDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.
P Annécie BenatrehinaDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.
Heebyung ChaiDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.
William J KellerNature's Sunshine Products, Inc. , 1655 North Main Street, Spanish Fork, Utah 84660, United States.
C Benjamin NamanDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.
A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.ORCID http://orcid.org/0000-0002-6647-8707

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
CHEMISTRY/BIOLOGY TRAINING GRANTT32GM008512 · NIGMS · OHIO STATE UNIVERSITY · PI PEI, DEHUA · 1996 to 2016
$3.9M
NCI NIH HHS P30 CA016058NIGMS NIH HHS T32 GM008512
6 · The paper itself

Abstract

Bioassay-guided phytochemical investigation of a commercially available maqui berry (Aristotelia chilensis) extract used in botanical dietary supplement products led to the isolation of 16 compounds, including one phenolic molecule, 1, discovered for the first time from a natural source, along with several known compounds, 2-16, including three substances not reported previously in A. chilensis, 2, 14, and 15. Each isolate was characterized by detailed analysis of NMR spectroscopic and HRESIMS data and tested for their in vitro hydroxyl radical scavenging and quinone-reductase inducing biological activities. A sensitive and accurate LC-DAD-MS method for the quantitative determination of the occurrence of six bioactive compounds, 6, 7, 10-12, and 14, was developed and validated using maqui berry isolates purified in the course of this study as authentic standards. The method presented can be utilized for dereplication efforts in future natural product research projects or to evaluate chemical markers for quality assurance and batch-to-batch standardization of this botanical dietary supplement component.

Indexed as

Anticarcinogenic AgentsAntioxidantsBiomarkersChromatography, High Pressure LiquidDietary SupplementsElaeocarpaceaeFree Radical ScavengersFruitLimit of DetectionMass SpectrometryMolecular StructurePhenolsPhytochemicalsPlant ExtractsReproducibility of ResultsAnticarcinogenic AgentsAntioxidantsBiomarkersFree Radical ScavengersPhenolsPhytochemicalsPlant ExtractsantioxidantsAristotelia chilensiscontent determinationHPLC−DAD-ESI/MShydroxyl radical-scavenging assaymaqui berryphloroglucinaldehyde 2-O-β-d-glucopyranosidequinone reductase-inducing assay

Identifiers

PMID28910091
PMCPMC5685509

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.