Evidence map›Paper›PMID 28906533›Full record

ArticleCardiovascular journal of Africa

Cardiac diastolic function after recovery from pre-eclampsia.

P Soma-Pillay, M C Louw, A O Adeyemo, J Makin, R C Pattinson

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular journal of Africa. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07190846 (Diastolic Dysfunction in the Pregnant Woman With Preeclampsia), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07190846 completednot on this map

Diastolic Dysfunction in the Pregnant Woman With Preeclampsia

Typeobservational_patient_registrySponsorUniversity Tunis El ManarRan2025 to 2025Enrolled80ConditionsPreeclampsia, Severe PreeclampsiaArmsNo Intervention (Observational Echocardiographic Evaluation)
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Cardiac Implications of Preeclampsia: A Review.Journal of personalized medicine · 2026
    Review
  4. Review
  5. Article
  6. Observational
  7. Review
  8. Article
  9. Review
  10. Preeclampsia and Fetal Congenital Heart Defects.Current cardiology reviews · 2022
    Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

P Soma-PillayCardiac Obstetric Unit, Department of Obstetrics and Gynaecology, University of Pretoria, Steve Biko Academic Hospital, Pretoria, South Africa; South African Medical Research Council; Maternal and Infant Health Care Strategies Unit, Department of Obstetrics and Gynaecology, University of Pretoria, Pretoria, South Africa. Email: soma-pillay@up.ac.za.
M C LouwDepartment of Cardiology, University of Pretoria, Steve Biko Academic Hospital, Pretoria, South Africa.
A O AdeyemoMediClinic Heart Hospital, Pretoria, South Africa.
J MakinSouth African Medical Research Council; Maternal and Infant Health Care Strategies Unit, Department of Obstetrics and Gynaecology, University of Pretoria, Pretoria, South Africa.
R C PattinsonSouth African Medical Research Council; Maternal and Infant Health Care Strategies Unit, Department of Obstetrics and Gynaecology, University of Pretoria, Pretoria, South Africa.
South African Medical Research Council · ZAUniversity of Pretoria · ZASteve Biko Hospital · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPre-eclampsia is associated with significant changes to the cardiovascular system during pregnancy. Eccentric and concentric remodelling of the left ventricle occurs, resulting in impaired contractility and diastolic dysfunction. It is unclear whether these structural and functional changes resolve completely after delivery.

aimsThe objective of the study was to determine cardiac diastolic function at delivery and one year post-partum in women with severe pre-eclampsia, and to determine possible future cardiovascular risk.

methodsThis was a descriptive study performed at Steve Biko Academic Hospital, a tertiary referral hospital in Pretoria, South Africa. Ninety-six women with severe preeclampsia and 45 normotensive women with uncomplicated pregnancies were recruited during the delivery admission. Seventy-four (77.1%) women in the pre-eclamptic group were classified as a maternal near miss. Transthoracic Doppler echocardiography was performed at delivery and one year post-partum.

resultsAt one year post-partum, women with pre-eclampsia had a higher diastolic blood pressure (p = 0.001) and body mass index (p = 0.02) than women in the normotensive control group. Women with early onset pre-eclampsia requiring delivery prior to 34 weeks' gestation had an increased risk of diastolic dysfunction at one year post-partum (RR 3.41, 95% CI: 1.11-10.5, p = 0.04) and this was irrespective of whether the patient had chronic hypertension or not.

conclusionWomen who develop early-onset pre-eclampsia requiring delivery before 34 weeks are at a significant risk of developing cardiac diastolic dysfunction one year after delivery compared to normotensive women with a history of a low-risk pregnancy.

Indexed as

Ventricular Function, LeftVentricular RemodelingAdolescentAdultCase-Control StudiesDiastoleFemaleGestational AgeHumansMiddle AgedPre-EclampsiaPregnancyPremature BirthRecovery of FunctionRisk FactorsSeverity of Illness Index

Identifiers

PMID28906533
PMCPMC6002791
OpenAlexW2792544891

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.