ReviewCardiovascular journal of Africa
The aetiology of cardiovascular disease: a role for mitochondrial DNA?
Review in Cardiovascular journal of Africa. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Mitochondrial related variants associated with cardiovascular traits.Frontiers in physiology · 2024Article
- Mitochondrial Genome Variation in Polish Elite Athletes.International journal of molecular sciences · 2023Article
- Androgen Excess Induced Mitochondrial Abnormality in Ovarian Granulosa Cells in a Rat Model of Polycystic Ovary Syndrome.Frontiers in endocrinology · 2022Article
- mtDNA in the Pathogenesis of Cardiovascular Diseases.Disease markers · 2021Article
- Mitochondrial DNA copy number is associated with all-cause mortality and cardiovascular events in patients with peripheral arterial disease.Journal of internal medicine · 2020Article
- Mitochondrial DNA Mutations and Rheumatic Heart Diseases.Journal of cardiovascular development and disease · 2019Article
- Mitochondrial genetic haplogroups and cardiovascular diseases: Data from the Osteoarthritis Initiative.PloS one · 2019Article
- New mtDNA Association Model, MutPred Variant Load, Suggests Individuals With Multiple Mildly Deleterious mtDNA Variants Are More Likely to Suffer From Atherosclerosis.Frontiers in genetics · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease (CVD) is a world-wide cause of mortality in humans and its incidence is on the rise in Africa. In this review, we discuss the putative role of mitochondrial dysfunction in the aetiology of CVD and consequently identify mitochondrial DNA (mtDNA) variation as a viable genetic risk factor to be considered. We then describe the contribution and pitfalls of several current approaches used when investigating mtDNA in relation to complex disease. We also propose an alternative approach, the adjusted mutational load hypothesis, which would have greater statistical power with cohorts of moderate size, and is less likely to be affected by population stratification. We therefore address some of the shortcomings of the current haplogroup association approach. Finally, we discuss the unique challenges faced by studies done on African populations, and recommend the most viable methods to use when investigating mtDNA variation in CVD and other common complex disease.
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Registered trials
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