ArticleLab on a chip2017
Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics.
Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- An Overview of Biopolymer-Based Graphene Nanocomposites for Biotechnological Applications.Materials (Basel, Switzerland) · 2025Review
- Emerging Trends in Microfluidic Biomaterials: From Functional Design to Applications.Journal of functional biomaterials · 2025Review
- Trends in Photopolymerization 3D Printing for Advanced Drug Delivery Applications.Biomacromolecules · 2025Review
- Facile photopatterning of perfusable microchannels in hydrogels for microphysiological systems.Nature protocols · 2025Review
- 3D-Printed Polymeric Biomaterials for Health Applications.Advanced healthcare materials · 2025Review
- Facile Photopatterning of Perfusable Microchannels in Synthetic Hydrogels to Recreate Microphysiological Environments.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Graphene oxide nanosheets augment silk fibroin aerogels for enhanced water stability and oil adsorption.Nanoscale advances · 2023Article
- Synthesis of a novel monofilament bioabsorbable suture for biomedical applications.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Shaping and Patterning Supramolecular Materials─Stem Cell-Compatible Dual-Network Hybrid Gels Loaded with Silver Nanoparticles.ACS biomaterials science & engineering · 2022Article
- Smart 3D Printed Hydrogel Skin Wound Bandages: A Review.Polymers · 2022Review
- Recent Advances in 3D Printing of Biomedical Sensing Devices.Advanced functional materials · 2022Article
- Advanced Strategies for 3D Bioprinting of Tissue and Organ Analogs Using Alginate Hydrogel Bioinks.Marine drugs · 2021Review
- Alginate-Based Smart Materials and Their Application: Recent Advances and Perspectives.Topics in current chemistry (Cham) · 2021Review
- Article
- Multiphoton Laser Fabrication of Hybrid Photo-Activable Biomaterials.Sensors (Basel, Switzerland) · 2021Review
- Can 3D Printing Bring Droplet Microfluidics to Every Lab?-A Systematic Review.Micromachines · 2021Review
- Complex 3D bioprinting methods.APL bioengineering · 2021Review
- Active biomaterials for mechanobiology.Biomaterials · 2021Review
- Biomaterials for Bioprinting Microvasculature.Chemical reviews · 2020Review
- Printability and Shape Fidelity of Bioinks in 3D Bioprinting.Chemical reviews · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
3D printed biomaterials with spatial and temporal functionality could enable interfacial manipulation of fluid flows and motile cells. However, such dynamic biomaterials are challenging to implement since they must be responsive to multiple, biocompatible stimuli. Here, we show stereolithographic printing of hydrogels using noncovalent (ionic) crosslinking, which enables reversible patterning with controlled degradation. We demonstrate this approach using sodium alginate, photoacid generators and various combinations of divalent cation salts, which can be used to tune the hydrogel degradation kinetics, pattern fidelity, and mechanical properties. This approach is first utilized to template perfusable microfluidic channels within a second encapsulating hydrogel for T-junction and gradient devices. The presence and degradation of printed alginate microstructures were further verified to have minimal toxicity on epithelial cells. Degradable alginate barriers were used to direct collective cell migration from different initial geometries, revealing differences in front speed and leader cell formation. Overall, this demonstration of light-based 3D printing using non-covalent crosslinking may enable adaptive and stimuli-responsive biomaterials, which could be utilized for bio-inspired sensing, actuation, drug delivery, and tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.