ArticleJournal of medical virology2018
Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection.
Article in Journal of medical virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Time Course Evaluation of Enzyme-Linked Immunosorbent Assays Based on Cell-Free Recombinant Proteins for Detection of Antibodies against Middle East Respiratory Syndrome Coronavirus.Microbiology spectrum · 2022Article
- Current diagnostic approaches to detect two important betacoronaviruses: Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Pathology, research and practice · 2021Review
- Middle East Respiratory Syndrome-Coronavirus Seropositive Bactrian Camels, Mongolia.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2021Article
- MERS-CoV: epidemiology, molecular dynamics, therapeutics, and future challenges.Annals of clinical microbiology and antimicrobials · 2021Review
- Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.Viruses · 2020Article
- Middle East Respiratory Syndrome (MERS) and novel coronavirus disease-2019 (COVID-19): From causes to preventions in Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Review
- SARS-CoV-2 S1 and N-based serological assays reveal rapid seroconversion and induction of specific antibody response in COVID-19 patients.Scientific reports · 2020Article
- Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient with COVID-19, Washington, USA.Emerging infectious diseases · 2020Article
- Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies.Emerging infectious diseases · 2020Article
- Focus on Middle East respiratory syndrome coronavirus (MERS-CoV).Medecine et maladies infectieuses · 2020Review
- Qualitative and Quantitative Determination of MERS-CoV S1-Specific Antibodies Using ELISA.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Evaluation of MERS-CoV Neutralizing Antibodies in Sera Using Live Virus Microneutralization Assay.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Research Progress on Coronavirus Prevention and Control in Animal-Source Foods.Journal of multidisciplinary healthcare · 2020Review
- Risk Factors for MERS-CoV Seropositivity among Animal Market and Slaughterhouse Workers, Abu Dhabi, United Arab Emirates, 2014-2017.Emerging infectious diseases · 2019Article
- Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia.Emerging infectious diseases · 2019Article
- Development and validation of different indirect ELISAs for MERS-CoV serological testing.Journal of immunological methods · 2019Article
- MERS coronavirus outbreak: Implications for emerging viral infections.Diagnostic microbiology and infectious disease · 2019Review
- Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels.Emerging microbes & infections · 2019Article
- Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017.Infection control and hospital epidemiology · 2019Article
- Infectious MERS-CoV Isolated From a Mildly Ill Patient, Saudi Arabia.Open forum infectious diseases · 2018Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
The Centers for Disease Control and Prevention (CDC) algorithm for detecting presence of serum antibodies against Middle East Respiratory Syndrome coronavirus (MERS-CoV) in subjects with potential infections with the virus has included screening by indirect ELISA against recombinant nucleocapsid (N) protein and confirmation by immunofluorescent staining of infected monolayers and/or microneutralization titration. Other international groups include indirect ELISA assays using the spike (S) protein, as part of their serological determinations. In the current study, we describe development and validation of an indirect MERS-CoV S ELISA to be used as part of our serological determination for evidence of previous exposure to the virus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.