ArticleJournal of anatomy2017
Merkel cells and Meissner's corpuscles in human digital skin display Piezo2 immunoreactivity.
Article in Journal of anatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The Lamellar Cells of Vertebrate Meissner and Pacinian Corpuscles: Development, Characterization, and Functions.Frontiers in neuroscience · 2022Pooled it
- Trapezius fascia reveals mechanosensory capacity and predominance of nociceptive axons in occipital neuralgia.Scientific reports · 2026Article
- Biological fundamental functional units of meridians: mechanosensitive ion channels.Frontiers in medicine · 2026Review
- Functional Characterization of a Novel Intronic Variant in PIEZO2 in a Recessive Form of Distal Arthrogryposis With Impaired Proprioception and Touch (DAIPT).Molecular genetics & genomic medicine · 2025Article
- Article
- Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.International journal of molecular sciences · 2024Article
- Editorial: Molecular and cellular bases of peripheral neuropathies.Frontiers in molecular neuroscience · 2024Article
- A helping hand: roles for accessory cells in the sense of touch across species.Frontiers in cellular neuroscience · 2024Review
- Article
- Sensorized Skin With Biomimetic Tactility Features Based on Artificial Cross-Talk of Bimodal Resistive Sensory Inputs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle.Science advances · 2023Article
- Merkel-like basal cells in the nasal septal island of dromedaries: Ultrastructure and possible functions.Saudi journal of biological sciences · 2023Article
- Spinal cord from body donors is suitable for multicolor immunofluorescence.Histochemistry and cell biology · 2023Article
- Review
- [Research advances on the function of skin touch receptor Merkel cells].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Tactile sensation in birds: Physiological insights from avian mechanoreceptors.Current opinion in neurobiology · 2022Review
- Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity.Journal of personalized medicine · 2022Article
- Human fetal skin derived merkel cells display distinctive characteristicsFrontiers in bioengineering and biotechnology · 2022Article
- Article
- Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transformation of mechanical energy into electrical signals is the first step in mechanotransduction in the peripheral sensory nervous system and relies on the presence of mechanically gated ion channels within specialized sensory organs called mechanoreceptors. Piezo2 is a vertebrate stretch-gated ion channel necessary for mechanosensitive channels in mammalian cells. Functionally, it is related to light touch, which has been detected in murine cutaneous Merkel cell-neurite complexes, Meissner-like corpuscles and lanceolate nerve endings. To the best of our knowledge, the occurrence of Piezo2 in human cutaneous mechanoreceptors has never been investigated. Here, we used simple and double immunohistochemistry to investigate the occurrence of Piezo2 in human digital glabrous skin. Piezo2 immunoreactivity was detected in approximately 80% of morphologically and immunohistochemically characterized (cytokeratin 20
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.