Evidence map›Paper›PMID 28905952›Full record

ArticleLab on a chip2017

Detection of membrane-bound and soluble antigens by magnetic levitation.

Mikkel Schou Andersen, Emily Howard, Shulin Lu, Matthew Richard, Mark Gregory, Gordon Ogembo, Ofer Mazor, Pavel Gorelik, Nathan I Shapiro, Anish V Sharda and 1 more

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Mikkel Schou AndersenDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, MA, USA.
Emily Howard
Shulin Lu
Matthew Richard
Mark Gregory
Gordon Ogembo
Ofer Mazor
Pavel Gorelik
Nathan I Shapiro
Anish V Sharda
Ionita Ghiran
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

Modulation of erythrocyte function by complementR01HL096795 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN · 2011 to 2014
$1.7M
Malaria screening in resource-poor settings using a simple, power-free, cell phone-friendly deviceR21TW009915 · FIC · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN · 2014 to 2015
$435k
FIC NIH HHS R21 TW009915NHLBI NIH HHS R01 HL096795
6 · The paper itself

Abstract

Magnetic levitation is a technique for measuring the density and the magnetic properties of objects suspended in a paramagnetic field. We describe a novel magnetic levitation-based method that can specifically detect cell membrane-bound and soluble antigens by measurable changes in levitation height that result from the formation of antibody-coated bead and antigen complex. We demonstrate our method's ability to sensitively detect an array of membrane-bound and soluble antigens found in blood, including T-cell antigen CD3, eosinophil antigen Siglec-8, red blood cell antigens CD35 and RhD, red blood cell-bound Epstein-Barr viral particles, and soluble IL-6, and validate the results by flow cytometry and immunofluorescence microscopy performed in parallel. Additionally, employing an inexpensive, single lens, manual focus, wifi-enabled camera, we extend the portability of our method for its potential use as a point-of-care diagnostic assay.

Indexed as

Antigens, SurfaceAntigens, ViralBlood CellsFlow CytometryHumansImmunomagnetic SeparationInterleukin-6Mobile ApplicationsSmartphoneAntigens, SurfaceAntigens, ViralInterleukin-6

Identifiers

PMID28905952
PMCPMC5642277
OpenAlexW2753919584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.