ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2017
Breeding and Rearing Naked Mole-Rats (
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Pup Recruitment in a Eusocial Mammal-Which Factors Influence Early Pup Survival in Naked Mole-Rats?Animals : an open access journal from MDPI · 2023Article
- Housing and Husbandry Alternatives for Naked Mole Rat Colonies Used in Research Settings.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Bacterial microbiome of faecal samples of naked mole-rat collected from the toilet chamber.BMC research notes · 2022Article
- Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits.ILAR journal · 2021Review
- Molecular basis for the evolved instability of a human G-protein coupled receptor.Cell reports · 2021Article
- Managed Care of Naked Mole-Rats.Advances in experimental medicine and biology · 2021Article
- Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats.Current biology : CB · 2020Article
- The microbiota in the intestinal and respiratory tracts of naked mole-rats revealed by high-throughput sequencing.BMC microbiology · 2018Article
- Comparative study of macrophages in naked mole rats and ICR mice.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unique biologic characteristics of naked mole-rats (NMR, Heterocephalus glaber) include longevity, cancer resistance, hypoxia tolerance, and pain insensitivity, making NMR an attractive model for biomedical research on aging, cancer, and neurobiology. However, breeding and rearing NMR in captivity is challenging. Here, we report a method for breeding NMR by using a closed-colony mating system. We selected sexually mature male and female NMR from different natal colonies and mated them 1:1. The 5 original colonies had an annual parity of 3.20 ± 0.84 (mean ± 1 SD), with 38.80 ± 9.50 pups born, 33.80 ± 8.32 pups weaned, and a survival rate of 87.19% ± 6.09% after weaning. The average annual parity of 22 N1 pairs (established from the progeny of the 5 original pairs) was 3.09 ± 0.81, with 34.86 ± 10.66 total pups born during the year, 30.14 ± 10.23 pups weaned, and a survival rate after weaning of 85.51% ± 6.60%. The average annual parity of 29 N2 pairs (that is, offspring of N1 pairs) was 3.04 ± 0.87, with 33.69 ± 11.42 pups born, 28.17 ± 10.43 pups weaned, and a survival rate after weaning of 83.66% ± 10.75%. None of these measures differed among the 3 generations, with average reproductive success exceeding 70% for each. In addition, the reproduction and growth of the N1 and N2 generations was similar to the original colonies. Our breeding method remarkably increases the production of NMR, thus representing a great potential to promote experimental NMR research and its applications.
Indexed as
Identifiers
28905723PMC5250503What OpenQuestion holds
Registered trials
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