ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2017
Use of Liposomal Bupivacaine for Postoperative Analgesia in an Incisional Pain Model in Rats (
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Effects of Extended-Release Liposomal Bupivacaine on Postoperative Mechanical and Thermal Hypersensitivity in C57BL/6 Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- The Analgesic Effect of Two Different Extended-Release Meloxicam Formulations for Attenuation of Hypersensitivity in Rats (Rattus norvegicus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A Review of Long-acting Parenteral Analgesics for Mice and Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Review
- Efficacy of 3 Buprenorphine Formulations for the Attenuation of Hypersensitivity after Plantar Incision in Immunodeficient NSG Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Effectiveness of two extended-release buprenorphine formulations during postoperative period in neonatal rats.PloS one · 2022Article
- Extended-release Buprenorphine, an FDAindexed Analgesic, Attenuates Mechanical Hypersensitivity in Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Mouse Anesthesia: The Art and Science.ILAR journal · 2021Review
- Lipid bound extended release buprenorphine (high and low doses) and sustained release buprenorphine effectively attenuate post-operative hypersensitivity in an incisional pain model in mice (Animal models and experimental medicine · 2021Article
- A novel excisional wound pain model for evaluation of analgesics in rats.The Korean journal of pain · 2021Article
- Article
- Clinical Management of Pain in Rodents.Comparative medicine · 2019Review
- Influence of Pain and Analgesia on Orthopedic and Wound-healing Models in Rats and Mice.Comparative medicine · 2019Review
- Preliminary Evaluation of Sustained-release Compared with Conventional Formulations of Meloxicam in Sheep (Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Evaluation of Analgesic Efficacy of Meloxicam and 2 Formulations of Buprenorphine after Laparotomy in Female Sprague-Dawley Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Transcriptional Changes in Dorsal Spinal Cord Persist after Surgical Incision Despite Preemptive Analgesia with Peripheral Resiniferatoxin.Anesthesiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The local anesthetic bupivacaine is valuable for perioperative analgesia, but its use in the postoperative period is limited by its short duration of action. Here, we evaluated the application of a slow-release liposomal formulation of bupivacaine for postoperative analgesia. The aim was to assess whether liposomal bupivacaine effectively attenuates postoperative mechanical and thermal hypersensitivity in a rat model of incisional pain. Rats (n = 36) were randomly assigned to 1 of 5 treatment groups: saline, 1 mL/kg SC every 12 h for 2 d; buprenorphine HCl, 0.05 mg/kg SC every 12 h for 2 d (Bup HCl); 0.5% bupivacaine, 2 mg/kg SC local infiltration once (Bupi); liposomal bupivacaine, 1 mg/kg SC local infiltration once (Exp1); and liposomal bupivacaine, 6 mg/kg SC local infiltration once (Exp6). Mechanical and thermal hypersensitivity were evaluated daily on days -1, 0, 1, 2, 3, and 4. The saline group exhibited both hypersensitivities through all 4 evaluated postoperative days. Bup HCl attenuated mechanical hypersensitivity for 2 d and thermal hypersensitivity for 1 d. Bupi attenuated only thermal hypersensitivity for 4 d. Rats in the Exp1 group showed attenuation of both mechanical and thermal hypersensitivity for 4 d, and those in the Exp6 group had attenuation of mechanical hypersensitivity on day 0 and thermal hypersensitivity for 4 d. These data suggest that a single local infiltration of liposomal bupivacaine at a dose of 1 mg/kg SC effectively attenuates postoperative mechanical and thermal hypersensitivity for 4 d in a rat model of incisional pain.
Indexed as
Identifiers
28905717PMC5250497W2988655598What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.