ArticleMolecular imaging and biology2018
An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[
Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Easy and versatile preparation ofEJNMMI radiopharmacy and chemistry · 2026Article
- Two F-18 radiochemistry methods to synthesize a promising transient receptor potential canonical 5 (TRPC5) radioligand.Journal of fluorine chemistry · 2024Article
- cGMP compliant one-step, one-pot automated [EJNMMI radiopharmacy and chemistry · 2024Article
- Scalable droplet-based radiosynthesis of [Lab on a chip · 2024Article
- Rapid Purification and Formulation of Radiopharmaceuticals via Thin-Layer Chromatography.Molecules (Basel, Switzerland) · 2022Article
- Development and preclinical evaluation of novel fluorinated ammonium salts for PET myocardial perfusion imaging.Scientific reports · 2021Article
- An Efficient Automated Radiosynthesis and Bioactivity Confirmation of VMAT2 Tracer [Molecular imaging and biology · 2020Article
- Article
- The Search for an Alternative to [Theranostics · 2019Review
- Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production.Journal of visualized experiments : JoVE · 2018Article
- High-throughput radio-TLC analysis.Nuclear medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe aim of this study was the automated synthesis of the mitochondrial membrane potential sensor 4-[ PROCEDURES: A three-pot, four-step synthesis was implemented on the ELIXYS FLEX/CHEM radiosynthesizer (Sofie Biosciences) and optimized for radiochemical yield (RCY), radiochemical purity (RCP) as well as chemical purity during several production runs (n = 24). The compound was purified by solid-phase extraction (SPE) with a Sep-Pak Plus Accell CM cartridge, thereby avoiding HPLC purification.
resultsUnder optimized conditions, AY of 1.4-2.2 GBq of [
conclusionsIn initial attempts, the probe was synthesized with RCY < 0.6 % when starting activities up to 44.6 GBq were used. Rapid radiolysis of the intermediate 4-[
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.