SynthesisEuropean child & adolescent psychiatry2018
ADHD is associated with migraine: a systematic review and meta-analysis.
Synthesis in European child & adolescent psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.Molecular psychiatry · 2026Pooled it
- Attention-deficit/hyperactivity disorder and chronic pain: a scoping review of epidemiology, clinical phenotypes, mechanisms, and treatment.Frontiers in psychiatry · 2026Pooled it
- The association between ADHD and physical health: a co-twin control study.Scientific reports · 2020Trial
- Functional Impairments and Adverse Outcomes Associated with ADHD: A Literature Review.Medicina (Kaunas, Lithuania) · 2026Review
- Attention-deficit/hyperactivity disorder and autism spectrum disorder in chronic pain: a study in Japanese pain centers.Scientific reports · 2026Article
- Headache Onset Timing as a Predictor for Comorbid Conditions of Pediatric Primary Headache.Medical sciences (Basel, Switzerland) · 2026Article
- Severity of migraine-like symptoms and its impact on executive functions in university students: a mediation model analysis.Primary health care research & development · 2025Article
- Headache symptoms in children and adolescents with ADHD: evaluating family history and the role of methylphenidate treatment.Acta neurologica Belgica · 2025Article
- Beyond the Pain: A Critical Examination of the Psychopathological and Neuropsychological Dimensions of Primary Headaches in Pediatric Populations.Life (Basel, Switzerland) · 2025Review
- Cognitive impairment and pain-related disability in patients with chronic pain: a mediation analysis.Pain reports · 2025Article
- ADHD (Attention-Deficit Hyperactivity Disorder) Symptoms Are Associated With Chronic Pain Interference: Results From a Prospective Cohort Study.Child: care, health and development · 2025Article
- Cyproheptadine Treatment in Children and Adolescents with Migraine: A Retrospective Study in Japan.Neurology international · 2024Article
- The impacts associated with having ADHD: an umbrella review.Frontiers in psychiatry · 2024Review
- Internalizing disorders rather than ADHD are risk factors for chronicity in pediatric migraine patients.Turkish journal of medical sciences · 2024Article
- Improvement in persistent idiopathic facial pain with comorbid ADHD using the combination of a dopamine system stabilizer and psychostimulant: A case report.Clinical case reports · 2023Article
- Enhancing attention in children using an integrated cognitive-physical videogame: A pilot study.NPJ digital medicine · 2023Article
- Article
- Diagnosis and treatment of intractable idiopathic orofacial pain with attention-deficit/hyperactivity disorder.Scientific reports · 2023Article
- Associations between Chronic Pain and Attention-Deficit Hyperactivity Disorder (ADHD) in Youth: A Scoping Review.Children (Basel, Switzerland) · 2023Article
- Case report: Remission of chronic low back pain and oral dysesthesia comorbid with attention deficit/hyperactivity disorder by treatment with atomoxetine and pramipexole.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An association between primary headaches and attention-deficit/hyperactivity disorder (ADHD) has long been suggested. Moreover, headache is regarded as a common side effect of stimulants, the most effective treatment for ADHD. So far, no systematic review has evaluated the potential association between ADHD and headache. We performed a systematic review of the literature and a meta-analysis of all reported studies on ADHD and primary headaches. Our analysis showed a positive association between ADHD and migraine (OR 1.322, 95% CI 1.018-1717, p value 0.036), but not with tension-type headache. There is a significant association between migraine and ADHD. The mechanisms underlying this association remain to be elucidated, warranting further studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.