ReviewBioMed research international2017
Responders to Platelet-Rich Plasma in Osteoarthritis: A Technical Analysis.
Review in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2023Pooled it
- Intra-articular injections of platelet-rich plasma in symptomatic knee osteoarthritis: a consensus statement from French-speaking experts.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Pooled it
- A comparative study of the efficacy of single and double centrifuged platelet-rich plasma and placebo (normal saline injection) on pain, ROM, and physical function of patients with knee osteoarthritis: a double-blinded controlled randomized trial with a six-month follow-up.Advances in rheumatology (London, England) · 2026Trial
- Comparison between the effects of ultrasound guided intra-articular injections of platelet-rich plasma (PRP), high molecular weight hyaluronic acid, and their combination in hip osteoarthritis: a randomized clinical trial.BMC musculoskeletal disorders · 2022Trial
- Safety and efficacy of a single intra-articular injection of a novel enhanced protein solution (JTA-004) compared to hylan G-F 20 in symptomatic knee osteoarthritis: a randomized, double-blind, controlled phase II/III study.BMC musculoskeletal disorders · 2021Trial
- Reply to the Letter to the Editor: Does the Combination of Platelet-rich Plasma and Supervised Exercise Yield Better Pain Relief and Enhanced Function in Knee Osteoarthritis? A Randomized Controlled Trial.Clinical orthopaedics and related research · 2024Article
- Platelet-Rich Plasma Injections in Chronic Lateral Ankle Instability: A Case Series.Biomedicines · 2024Article
- Platelet-Rich Plasma for Knee Osteoarthritis: What Does the Evidence Say?Drugs & aging · 2023Review
- Prognostic Factors Related to Clinical Response in 210 Knees Treated by Platelet-Rich Plasma for Osteoarthritis.Diagnostics (Basel, Switzerland) · 2023Article
- Challenges and opportunities of pharmacological interventions for osteoarthritis: A review of current clinical trials and developments.Osteoarthritis and cartilage open · 2021Review
- The immature platelet fraction affects the efficacy of platelet rich plasma therapy for knee osteoarthritis.Regenerative therapy · 2021Article
- Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: a pilot study.Regenerative medicine · 2021Article
- Intra-Articular Injections in Knee Osteoarthritis: A Review of Literature.Journal of functional morphology and kinesiology · 2021Review
- Hyaluronic acid and platelet-rich plasma for the management of knee osteoarthritis.International orthopaedics · 2021Review
- Intraosseous infiltrations of Platelet-Rich Plasma for severe hip osteoarthritis: A pilot study.Journal of clinical orthopaedics and trauma · 2020Article
- Alternative and complementary therapies in osteoarthritis and cartilage repair.Aging clinical and experimental research · 2020Review
- A Comparative Study of The Effects of Anticoagulants on Pure Platelet-Rich Plasma Quality and Potency.Biomedicines · 2020Article
- Concentrated Growth Factor Matrices Prepared Using Silica-Coated Plastic Tubes Are Distinguishable From Those Prepared Using Glass Tubes in Platelet Distribution: Application of a Novel Near-Infrared Imaging-Based, Quantitative Technique.Frontiers in bioengineering and biotechnology · 2020Article
- Efficiency of platelet-rich plasma therapy in knee osteoarthritis does not depend on level of cartilage damage.Journal of orthopaedic surgery and research · 2019Article
- Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. MATERIALS AND
methodsA comparison of the outcomes of randomized controlled trials (RCTs) included in the 3 most recent and high-quality meta-analyses to classify the different studies in 2 groups (bad responders group (BRG) and very good responders group (VGRG)). RESULTS AND DISCUSSION: From the 19 RCTs analyzed, 7 trials were included in the VGRG and 4 in the BRG. In VGRG, 1 or 2 injections were performed in 4/7 trials, time between injections was 2 to 3 weeks in 4/5 studies with many injections, volume injected varied from 2.5 to 8 mL, and single spinning technique was used in 5/7 studies. PRP classification was Mishra 4B and PAWP2B
conclusionThere is a lack of standardization in PRP preparation technique for knee osteoarthritis. However it appears that the use of a single spinning technique, a platelet concentration lower than 5 times the baseline, and avoidance of leukocytes should be preferred.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.