ArticleBMC hematology2017
Alterations in hematologic indices during long-duration spaceflight.
Article in BMC hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Introducing the Concept of Exercise Holidays for Human Spaceflight - What Can We Learn From the Recovery of Bed Rest Passive Control Groups.Frontiers in physiology · 2022Pooled it
- Women in space: A review of known physiological adaptations and health perspectives.Experimental physiology · 2026Review
- Volumetric Absorptive Microsampling During Spaceflight for Analysis of Acetaminophen Pharmacokinetics in Whole Blood.Journal of clinical pharmacology · 2026Article
- Epigenomic profiling of immune cell subtypes reveals H3K27ac-marked stress signatures after long-duration spaceflight.Scientific reports · 2025Article
- Physiological Changes in the Cardiovascular System During Space Flight - Current Countermeasures and Future Vision.Circulation reports · 2025Review
- Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity.Stem cell research & therapy · 2025Article
- Pulmonary and systemic immune alterations in rats exposed to airborne lunar dust.Frontiers in immunology · 2025Article
- Carotid wall structure during and after 6 months of spaceflight.Frontiers in physiology · 2025Article
- Sex-specific cardiovascular adaptations to simulated microgravity in Sprague-Dawley rats.NPJ microgravity · 2024Article
- Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).Nature communications · 2024Article
- Transcriptomic evidence of erythropoietic adaptation from the International Space Station and from an Earth-based space analog.NPJ microgravity · 2024Article
- Understanding the complexities of space anaemia in extended space missions: revelations from microgravitational odyssey.Frontiers in physiology · 2024Article
- Countermeasures for Maintaining Cardiovascular Health in Space Missions.Current cardiology reviews · 2023Article
- Review
- Understanding the Behaviour of Human Cell Types under Simulated Microgravity Conditions: The Case of Erythrocytes.International journal of molecular sciences · 2022Article
- Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature.British journal of pharmacology · 2022Review
- B-Cell Homeostasis Is Maintained During Two Months of Head-Down Tilt Bed Rest With or Without Antioxidant Supplementation.Frontiers in immunology · 2022Article
- Facing Trauma and Surgical Emergency in Space: Hemorrhagic Shock.Frontiers in bioengineering and biotechnology · 2022Review
- Post-Transcriptional Dynamics is Involved in Rapid Adaptation to Hypergravity in Jurkat T Cells.Frontiers in cell and developmental biology · 2022Article
- The Cardiovascular System in Space: Focus on In Vivo and In Vitro Studies.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough a state of anemia is perceived to be associated with spaceflight, to date a peripheral blood hematologic assessment of red blood cell (RBC) indices has not been performed during long-duration space missions.
methodsThis investigation collected whole blood samples from astronauts participating in up to 6-months orbital spaceflight, and returned those samples (ambient storage) to Earth for analysis. As samples were always collected near undock of a returning vehicle, the delay from collection to analysis never exceeded 48 h. As a subset of a larger immunologic investigation, a complete blood count was performed. A parallel stability study of the effect of a 48 h delay on these parameters assisted interpretation of the in-flight data.
resultsWe report that the RBC and hemoglobin were significantly elevated during flight, both parameters deemed stable through the delay of sample return. Although the stability data showed hematocrit to be mildly elevated at +48 h, there was an in-flight increase in hematocrit that was ~3-fold higher in magnitude than the anticipated increase due to the delay in processing.
conclusionsWhile susceptible to the possible influence of dehydration or plasma volume alterations, these results suggest astronauts do not develop persistent anemia during spaceflight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.