ReviewStem cells international2017
Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche.
Review in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Pooled it
- Bioactive-Supplemented Infant Formulas and Early Gut-Immune-Endocrine Development: A Narrative Review.International journal of molecular sciences · 2026Review
- A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a Hopx-associated program.Nature communications · 2026Article
- An organoid-based evaluation of Bacillus amyloliquefaciens SC06 in alleviating oxidative damage via Wnt signaling.BMC veterinary research · 2026Article
- Microbiota from young mice restore the function of aged ISCs.Stem cell reports · 2026Article
- Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing.Nature communications · 2026Article
- Remodeling the gut microbiota: mechanistic insights into probiotic-mediated alleviation of weaning stress in piglets.Frontiers in immunology · 2026Review
- Gut Microbial Metabolites of Tryptophan Augment Enteroendocrine Cell Differentiation in Human Colonic Organoids: Therapeutic Potential for Dysregulated GLP1 Secretion in Obesity.International journal of molecular sciences · 2025Article
- In preprints: are microbes the architects of animal bodies?Development (Cambridge, England) · 2025Article
- Microbial sensing in the intestine.Protein & cell · 2023Review
- Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study.Biomedical journal · 2023Article
- Lasting consequences on physiology and social behavior following cesarean delivery in prairie voles.Hormones and behavior · 2023Article
- THE SMALL INTESTINAL MICROBIOME: VIBING WITH INTESTINAL STEM CELLS.Microbiota and host · 2023Article
- The Protective Effects of Nutraceutical Components in Methotrexate-Induced Toxicity Models-An Overview.Microorganisms · 2022Review
- Effects of Immune Cells on Intestinal Stem Cells: Prospects for Therapeutic Targets.Stem cell reviews and reports · 2022Review
- Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease.Scientific reports · 2022Article
- Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation.Cell reports · 2022Article
- A Special Network Comprised of Macrophages, Epithelial Cells, and Gut Microbiota for Gut Homeostasis.Cells · 2022Review
- Cross-Talk Between the Intestinal Epithelium andFrontiers in microbiology · 2022Review
- Integrated Omics Analysis Reveals Alterations in the Intestinal Microbiota and Metabolites of Piglets After Starvation.Frontiers in microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian intestinal epithelial stem cell (IESC) niche is comprised of diverse epithelial, immune, and stromal cells, which together respond to environmental changes within the lumen and exert coordinated regulation of IESC behavior. There is growing appreciation for the role of the gut microbiota in modulating intestinal proliferation and differentiation, as well as other aspects of intestinal physiology. In this review, we evaluate the diverse roles of known niche cells in responding to gut microbiota and supporting IESCs. Furthermore, we discuss the potential mechanisms by which microbiota may exert their influence on niche cells and possibly on IESCs directly. Finally, we present an overview of the benefits and limitations of available tools to study niche-microbe interactions and provide our recommendations regarding their use and standardization. The study of host-microbe interactions in the gut is a rapidly growing field, and the IESC niche is at the forefront of host-microbe activity to control nutrient absorption, endocrine signaling, energy homeostasis, immune response, and systemic health.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.