Evidence map›Paper›PMID 28904509›Full record

ArticleShanghai archives of psychiatry2017

Peripheral SLC6A4 Gene Expression in Obsessive-Compulsive Disorder in the Han Chinese Population.

Xuemei Wang, Qing Zhao, Wen Chen, Shunying Yu, Zhen Wang, Zeping Xiao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Shanghai archives of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xuemei WangThe First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Qing ZhaoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wen ChenThe First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Shunying YuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhen WangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zeping XiaoShanghai Jiao Tong University School of Medicine, 227 Chong Qing Nan Rd, Shanghai, China.
Shanghai Mental Health Center · CNFirst Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerotonergic system dysfunction has been implicated in obsessive-compulsive disorder (OCD). This study examined peripheral SLC6A4 gene expression in OCD patients and healthy controls to explore the relationship between SLC6A4 and OCD.

methodsParticipants included 50 first episode OCD patients and 60 age and gender-matched healthy controls. Relative SLC6A4 gene expression were examined by real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) in peripheral leukocytes of all the subjects. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to assess the severity and subtype of OCD.

resultsSLC6A4 gene expression, normalized by glyceraldehyde-3-phosphate dehydrogenase (GAPDH), were not significantly different between the OCD patients and healthy controls(

conclusionThere is no correlation between SLC6A4 expression levels and the severity and subtype of OCD, but male OCD patients showed a tendency of low gene expression of SLC6A4 in peripheral blood. These results suggest that gene expression of SLC6A4 in peripheral blood may not be a useful biomarker of OCD in the Han Chinese population.

Indexed as

gene expressionOCDRT-PCRSLC6A4Yale–Brown Obsessive-Compulsive Scale score(Y-BOCS)

Identifiers

PMID28904509
PMCPMC5579458
OpenAlexW2953260699

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.