Evidence map›Paper›PMID 28904410›Full record

ReviewIndian journal of microbiology2017

Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in

Zhihong Hu, Bin He, Long Ma, Yunlong Sun, Yali Niu, Bin Zeng

Open access · bronzeAbstract readReview
In one paragraph

Review in Indian journal of microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 208 citations in OpenAlex.

  1. High-level amyrin production inSynthetic and systems biotechnology · 2027
    Article
  2. Article
  3. Article
  4. Review
  5. Metabolic Engineering for Gibberellic Acid Production inMolecules (Basel, Switzerland) · 2026
    Review
  6. Article
  7. Article
  8. EngineeringSynthetic and systems biotechnology · 2026
    Article
  9. Fermentation techniques for protein enrichment of cassava peel.Journal of the science of food and agriculture · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Biosynthesis of lanosterol inSynthetic and systems biotechnology · 2025
    Article
  17. Csn5 Depletion Reverses Mitochondrial Defects in GCN5-NullInternational journal of molecular sciences · 2025
    Article
  18. Article
  19. Article
  20. Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhihong HuJiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In Vitro Diagnosti Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang, 330013 China.
Bin HeJiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In Vitro Diagnosti Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang, 330013 China.
Long MaJiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In Vitro Diagnosti Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang, 330013 China.
Yunlong SunJiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In Vitro Diagnosti Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang, 330013 China.
Yali NiuJiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In Vitro Diagnosti Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang, 330013 China.
Bin ZengJiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In Vitro Diagnosti Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang, 330013 China.
Jiangxi Science and Technology Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ergosterol, an important component of the fungal cell membrane, is not only essential for fungal growth and development but also very important for adaptation to stress in fungi. Ergosterol is also a direct precursor for steroid drugs. The biosynthesis of ergosterol can be divided into three modules: mevalonate, farnesyl pyrophosphate (farnesyl-PP) and ergosterol biosynthesis. The regulation of ergosterol content is mainly achieved by feedback regulation of ergosterol synthase activity through transcription, translation and posttranslational modification. The synthesis of HMG-CoA, catalyzed by HMGR, is a major metabolic check point in ergosterol biosynthesis. Excessive sterols can be subsequently stored in lipid droplets or secreted into the extracellular milieu by esterification or acetylation to avoid toxic effects. As sterols are insoluble, the intracellular transport of ergosterol in cells requires transporters. In recent years, great progress has been made in understanding ergosterol biosynthesis and its regulation in

Indexed as

BiosynthesisErgosterolRegulationSaccharomyces cerevisiaeTransportation

Identifiers

PMID28904410
PMCPMC5574775
OpenAlexW2733705455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.