ArticleScientific reports2017
Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
130 citing papers in PubMed, 782 citations in OpenAlex.
- Polarization Holographic 4D Phenotyping Reveals Nanoplastic Induced Dysfunction in Zooplankton.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microbial Inoculant-Driven Degradation of Microplastics Associated With Garbage Environment and Assessment of Degradation Product Toxicity.Biotechnology and bioengineering · 2026Article
- The Effects of Microplastics and Additives on Ecosystem Function, Structure, and Signaling.Global change biology · 2026Review
- Review
- Article
- Occurrence and Characterization of Microplastics in Gilthead Seabream (Foods (Basel, Switzerland) · 2026Article
- Dose-dependent acute toxicity of chitosan nanoparticles with dual assessment of multisystem toxicopathology and oxidative stress biomarkers in Nile tilapia.Scientific reports · 2026Article
- Exposure to Nanoplastics Disrupts Neurotransmitter Release in Rat Hippocampal Neurons.Environment & health (Washington, D.C.) · 2026Article
- Synthesis of Poly(δ-valerolactone)-poly(Macromolecules · 2026Article
- Microplastics Interception from Riverine Ecosystems and Translocation to Fish Internal Organs.Scientific reports · 2026Article
- Neurophysiological and Behavioral Effects of Micro- and Nanoplastics in Aquatic Organisms.Animals : an open access journal from MDPI · 2026Review
- Biological alterations of polyvinyl chloride (PVC) microplastics on Danio rerio at environmentally relevant concentrations - risk assessment.Fish physiology and biochemistry · 2026Article
- Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives.Archives of toxicology · 2026Review
- Engineering ofMicroorganisms · 2026Article
- Preliminary study of polyethylene microplastics disrupting energy Metabolism, redox Balance, and prefrontal cortex structure in Wistar rats.Scientific reports · 2026Article
- Article
- Microplastics Induced Dysfunctions in Physiology and Behavior of Fish: A Comprehensive Review.Journal of toxicology · 2026Review
- Microplastic toxicity: mechanisms, assessment methods, and future research directions.Frontiers in toxicology · 2026Review
- Postbiotic sequestration of micro- and nanoplastics:Frontiers in microbiology · 2026Article
- Plastics as disruptors of feeding, digestive physiology, metabolism, and growth in fish and other aquatic ectothermic vertebrates.Frontiers in endocrinology · 2026Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tremendous increases in production of plastic materials has led to an accumulation of plastic pollution worldwide. Many studies have addressed the physical effects of large-sized plastics on organisms, whereas few have focused on plastic nanoparticles, despite their distinct chemical, physical and mechanical properties. Hence our understanding of their effects on ecosystem function, behaviour and metabolism of organisms remains elusive. Here we demonstrate that plastic nanoparticles reduce survival of aquatic zooplankton and penetrate the blood-to-brain barrier in fish and cause behavioural disorders. Hence, for the first time, we uncover direct interactions between plastic nanoparticles and brain tissue, which is the likely mechanism behind the observed behavioural disorders in the top consumer. In a broader perspective, our findings demonstrate that plastic nanoparticles are transferred up through a food chain, enter the brain of the top consumer and affect its behaviour, thereby severely disrupting the function of natural ecosystems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.