ArticleScience translational medicine2017
Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects.
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Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
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Who cites it
46 citing papers in PubMed, 87 citations in OpenAlex.
- Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States.Cell reports · 2020Trial
- Dysfunctional adipose tissue-lymphatic crosstalk in obesity.Nature reviews. Endocrinology · 2026Review
- Endothelial Cells as Active Lipid Gatekeepers: Vascular Control of Lipid Handling and Metabolic Homeostasis.Nutrients · 2026Review
- The Apelinergic System in Kidney Disease: Novel Perspectives.International journal of molecular sciences · 2025Review
- Endothelial cell metabolism in cardiovascular physiology and disease.Nature reviews. Cardiology · 2025Review
- Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development.Journal of biomedical science · 2025Review
- In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor.Nature communications · 2025Article
- Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Silencing APLNR enhances the radiosensitivity of prostate cancer by modulating the PI3K/AKT/mTOR signaling pathway.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Review
- Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications.Biomedicines · 2024Review
- Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights.International journal of emergency medicine · 2024Review
- Thrombolysis exacerbates cerebrovascular injury after ischemic stroke via a VEGF-B dependent effect on adipose lipolysis.bioRxiv : the preprint server for biology · 2024Article
- Spatiotemporal evolutionary process of osteosarcoma immune microenvironment remodeling and C1QBP-driven drug resistance deciphered through single-cell multi-dimensional analysis.Bioengineering & translational medicine · 2024Article
- Effects of in utero exposure to Δ-9-tetrahydrocannabinol on cardiac extracellular matrix expression and vascular transcriptome in rhesus macaques.American journal of physiology. Heart and circulatory physiology · 2024Article
- Neural progenitor-derived Apelin controls tip cell behavior and vascular patterning.Science advances · 2024Article
- Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies.Cardiovascular toxicology · 2023Review
- Exercise improves homeostasis of the intestinal epithelium by activation of apelin receptor-AMP-activated protein kinase signalling.The Journal of physiology · 2023Article
- Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes.Nature communications · 2023Article
- GPCR in Adipose Tissue Function-Focus on Lipolysis.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Cheol HwangboYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.ORCID http://orcid.org/0000-0001-6505-3080
Jingxia WuYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.ORCID http://orcid.org/0000-0002-7573-4741
Irinna PapangeliYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.ORCID http://orcid.org/0000-0002-3151-4237
Takaomi AdachiYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.ORCID http://orcid.org/0000-0003-3160-1872
Bikram SharmaDepartment of Biology, Stanford University, Stanford, CA 94304, USA.
Saejeong ParkYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.
Lina ZhaoYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.
Hyekyung JuYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.
Gwang-Woong GoYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.ORCID http://orcid.org/0000-0002-3848-8705
Guoliang CuiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.ORCID http://orcid.org/0000-0001-5559-7957
Mohammed InayathullahBiomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA.ORCID http://orcid.org/0000-0001-7646-1709
Judith K JobBiomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA.ORCID http://orcid.org/0000-0002-2393-5613
Jayakumar RajadasBiomaterials and Advanced Drug Delivery Laboratory, Stanford University, Stanford, CA 94304, USA.
Stephanie L KweiSection of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, CT 06511, USA.
Ming O LiImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID http://orcid.org/0000-0002-1383-0535
Alan R MorrisonYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.ORCID http://orcid.org/0000-0002-2412-7669
Thomas QuertermousDivision of Cardiovascular Medicine, Stanford University, Stanford, CA 94304, USA.ORCID http://orcid.org/0000-0002-7645-9067
Arya ManiYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA.ORCID http://orcid.org/0000-0001-6699-259X
Kristy Red-HorseDepartment of Biology, Stanford University, Stanford, CA 94304, USA.
Hyung J ChunYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA. hyung.chun@yale.edu.ORCID http://orcid.org/0000-0003-3508-2678
Yale University · USStanford University · USCardiovascular Institute of the South · USMemorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MUncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI ROUNDS, SHARON IRENE SMITH · 2013 to 2022
$21.3MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MThe Identification and characterization of genetic variants underlying cardiovascular diseasesR35HL135767 · NHLBI · YALE UNIVERSITY · PI MANI, ARYA · 2017 to 2023
$7.0MVanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3MMechanotransduction and transcriptional regulation during artery developmentR01HL128503 · NHLBI · STANFORD UNIVERSITY · PI Mary Red-Horse · 2015 to 2026
$5.8MNutrient Sensing and mTORC1 Signaling in the Control of Regulatory T Cell Generation and FunctionR01AI102888 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI LI, MING · 2014 to 2022
$4.3MRole of MicroRNAs 424 and 503 in Pulmonary Arterial HypertensionR01HL113005 · NHLBI · YALE UNIVERSITY · PI CHUN, HYUNG JOON · 2012 to 2016
$2.0MInvestigation of genetic and physiological causes of inherited Vascular and MetabR01HL094784 · NHLBI · YALE UNIVERSITY · PI MANI, ARYA · 2009 to 2013
$2.0MYale Cardiovascular Center faculty recruitmentP30HL101284 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 2009 to 2010
$1.2MRole of Apelin in the Systemic and Pulmonary VasculatureK08HL095654 · NHLBI · YALE UNIVERSITY · PI CHUN, HYUNG JOON · 2009 to 2013
$668kBLRD VA IK2 BX002527NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NHLBI NIH HHS K08 HL095654NHLBI NIH HHS P30 HL101284NHLBI NIH HHS R01 HL094784NHLBI NIH HHS R01 HL113005NHLBI NIH HHS R01 HL128503NHLBI NIH HHS R35 HL135767NIAID NIH HHS R01 AI102888NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637NIGMS NIH HHS P20 GM103652
Abstract
Treatment of type 2 diabetes mellitus continues to pose an important clinical challenge, with most existing therapies lacking demonstrable ability to improve cardiovascular outcomes. The atheroprotective peptide apelin (APLN) enhances glucose utilization and improves insulin sensitivity. However, the mechanism of these effects remains poorly defined. We demonstrate that the expression of APLNR (APJ/AGTRL1), the only known receptor for apelin, is predominantly restricted to the endothelial cells (ECs) of multiple adult metabolic organs, including skeletal muscle and adipose tissue. Conditional endothelial-specific deletion of
Indexed as
AgingAnimalsApelinApelin ReceptorsEndotheliumFatty Acid-Binding ProteinsFatty AcidsForkhead Box Protein O1GlucoseHumansHuman Umbilical Vein Endothelial CellsMaleMice, KnockoutSignal TransductionApelinApelin ReceptorsFabp4 protein, mouseFatty Acid-Binding ProteinsFatty AcidsForkhead Box Protein O1Foxo1 protein, mouseGlucose
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.