ArticleJournal of neurophysiology2017
Methodological considerations for a chronic neural interface with the cuneate nucleus of macaques.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Amorphous silicon carbide probe mechanics for insertion in the cerebral cortex of rats, pigs, and macaques.Journal of neural engineering · 2025Article
- Restoration of sensory information via bionic hands.Nature biomedical engineering · 2023Review
- Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?Annual review of physiology · 2023Review
- The science and engineering behind sensitized brain-controlled bionic hands.Physiological reviews · 2022Review
- Sensory computations in the cuneate nucleus of macaques.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Modulation of tactile feedback for the execution of dexterous movement.Science (New York, N.Y.) · 2021Article
- Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.Micromachines · 2021Review
- Encoding of limb state by single neurons in the cuneate nucleus of awake monkeys.Journal of neurophysiology · 2021Article
- Cuneate nucleus: The somatosensory gateway to the brain.Current opinion in physiology · 2021Article
- Article
- Dorsal Column Nuclei Neural Signal Features Permit Robust Machine-Learning of Natural Tactile- and Proprioception-Dominated Stimuli.Frontiers in systems neuroscience · 2020Article
- Restoring Somatosensation: Advantages and Current Limitations of Targeting the Brainstem Dorsal Column Nuclei Complex.Frontiers in neuroscience · 2020Article
- Mechanical vibration does not systematically reduce the tremor in essential tremor patients.Scientific reports · 2019Article
- Peripheral Nerve Activation Evokes Machine-Learnable Signals in the Dorsal Column Nuclei.Frontiers in systems neuroscience · 2019Article
- Neural Basis of Touch and Proprioception in Primate Cortex.Comprehensive Physiology · 2018Review
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
While the response properties of neurons in the somatosensory nerves and anterior parietal cortex have been extensively studied, little is known about the encoding of tactile and proprioceptive information in the cuneate nucleus (CN) or external cuneate nucleus (ECN), the first recipients of upper limb somatosensory afferent signals. The major challenge in characterizing neural coding in CN/ECN has been to record from these tiny, difficult-to-access brain stem structures. Most previous investigations of CN response properties have been carried out in decerebrate or anesthetized animals, thereby eliminating the well-documented top-down signals from cortex, which likely exert a strong influence on CN responses. Seeking to fill this gap in our understanding of somatosensory processing, we describe an approach to chronically implanting arrays of electrodes in the upper limb representation in the brain stem in primates. First, we describe the topography of CN/ECN in rhesus macaques, including its somatotopic organization and the layout of its submodalities (touch and proprioception). Second, we describe the design of electrode arrays and the implantation strategy to obtain stable recordings. Third, we show sample responses of CN/ECN neurons in brain stem obtained from awake, behaving monkeys. With this method, we are in a position to characterize, for the first time, somatosensory representations in CN and ECN of primates.
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