Evidence map›Paper›PMID 28904081›Full record

ArticlePhysiological reports2017

Variable setpoint as a relaxing component in physiological control.

Geir B Risvoll, Kristian Thorsen, Peter Ruoff, Tormod Drengstig

Abstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Universal structural requirements for maximal robust perfect adaptation in biomolecular networks.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. CoRa-A general approach for quantifying biological feedback control.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Sodium, volume and pressure control in haemodialysis patients for improved cardiovascular outcomes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Geir B RisvollDepartment of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway.
Kristian ThorsenDepartment of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway.
Peter RuoffCentre for Organelle Research, University of Stavanger, Stavanger, Norway.
Tormod DrengstigDepartment of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway tormod.drengstig@uis.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Setpoints in physiology have been a puzzle for decades, and especially the notion of fixed or variable setpoints have received much attention. In this paper, we show how previously presented homeostatic controller motifs, extended with saturable signaling kinetics, can be described as variable setpoint controllers. The benefit of a variable setpoint controller is that an observed

Indexed as

Feedback, PhysiologicalModels, BiologicalWater-Electrolyte BalanceAldosteroneAnimalsHumansKidneySodiumAldosteroneSodiumIntegral controlnegative feedbackrheostasissodium homeostasisvariable setpoint

Identifiers

PMID28904081
PMCPMC5599866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.