ReviewJournal of the American Society of Nephrology : JASN2017
Assessing Microvascular Function in Humans from a Chronic Disease Perspective.
Review in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07240103 (Blood-Interstitial Fluid Glucose Gap), which is not on this map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Blood-Interstitial Fluid Glucose Gap: A Novel Indicator for Assessing Metabolic Status and Mortality Risk in Critically Ill Patients
Who cites it
71 citing papers in PubMed, 136 citations in OpenAlex.
- The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness.Physiological reports · 2025Trial
- The effect of four weeks blood flow restricted resistance training on macro- and micro-vascular function in healthy, young men.European journal of applied physiology · 2023Trial
- High-salt intake affects retinal vascular tortuosity in healthy males: an exploratory randomized cross-over trial.Scientific reports · 2021Trial
- Dietary supplementation with whey protein improves systemic microvascular function in heart failure patients: a pilot study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Trial
- Trial
- Multiparametric MRI for Early Chronic Kidney Disease Detection: Insights Into Renal Microcirculation.NMR in biomedicine · 2026Article
- Effects of Nitrate- and Betalain-Rich Beetroot Juice Ingestion on Vascular Function and Metabolic Syndrome Risk Factors in Healthy Adults: A Pilot Study.Metabolites · 2026Article
- Relations of Life's Essential 8 score with arterial and microvascular function: The Jackson Heart Study.Vascular medicine (London, England) · 2026Article
- Examination of post-exercise microvascular reactivity in healthy adults.European journal of applied physiology · 2026Article
- Link between physical activity, nutrition, and antimicrobial pharmacokinetics and therapeutic efficacy: Implications for resistance management.SAGE open medicine · 2026Review
- A General-Purpose Framework for Microvascular Reconstruction and Quantitative Analysis in Ultrasound Localization Microscopy.BME frontiers · 2026Article
- Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study.Cardiovascular diabetology · 2025Article
- Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease.Investigative ophthalmology & visual science · 2025Article
- Nomogram models for predicting myocardial ischemia under high altitude exposure: a cohort study.Scientific reports · 2024Article
- The Effect of Overweight/Obesity on Cutaneous Microvascular Reactivity as Measured by Laser-Doppler Fluxmetry: A Systematic Review.Biomedicines · 2024Review
- Tissue-Engineered Microvessels: A Review of Current Engineering Strategies and Applications.Advanced healthcare materials · 2024Review
- Article
- Looking into the Eyes to See the Heart of Chronic Kidney Disease Patients.Life (Basel, Switzerland) · 2024Article
- A Novel Method for the Measurement of Retinal Arteriolar Bifurcation.Ophthalmology and therapy · 2024Article
- Ocular microvascular alteration in patients with myocardial infarction-a new OCTA study.Scientific reports · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microvascular dysfunction (MVD) is considered a crucial pathway in the development and progression of cardiometabolic and renal disease and is associated with increased cardiovascular mortality. MVD often coexists with or even precedes macrovascular disease, possibly due to shared mechanisms of vascular damage, such as inflammatory processes and oxidative stress. One of the first events in MVD is endothelial dysfunction. With the use of different physiologic or pharmacologic stimuli, endothelium-dependent (micro)vascular reactivity can be studied. This reactivity depends on the balance between various mediators, including nitric oxide, endothelin, and prostanoids, among others. The measurement of microvascular (endothelial) function is important to understand the pathophysiologic mechanisms that contribute to MVD and the role of MVD in the development and progression of cardiometabolic/renal disease. Here, we review a selection of direct, noninvasive techniques for measuring human microcirculation, with a focus on methods, interpretation, and limitations from the perspective of chronic cardiometabolic and renal disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.