ArticleJournal of the American Heart Association2017
Atrial Fibrillation in Acute Obstructive Sleep Apnea: Autonomic Nervous Mechanism and Modulation.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Obstructive Sleep Apnea and Cardiovascular Disease: Mechanisms, Diagnostics, and Emerging Therapeutic Approaches.Biomedicines · 2026Review
- Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics - 2024 update.The Journal of physiology · 2025Review
- The effect of continuous positive airway pressure therapy on atrial fibrillation in patients with obstructive sleep apnea.Frontiers in medicine · 2025Review
- Phrenic Nerve Stimulation for Central Sleep Apnoea: When and Why?Cardiac failure review · 2025Review
- Non-invasive Neuromodulation of Arrhythmias.Cardiac electrophysiology clinics · 2024Review
- Exploring the bidirectional relationship between sleep disorders and atrial fibrillation: implications for risk stratification and management.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Review
- Development of neuromodulation for atrial fibrillation: a narrative review.Journal of thoracic disease · 2024Review
- The Effects of Obstructive Sleep Apnea on the Cardiovascular System: A Comprehensive Review.Journal of clinical medicine · 2024Review
- Evaluate the Relationship Between Obstructive Sleep Apnea and Metabolic Syndrome in Real-World Data.Nature and science of sleep · 2024Article
- Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome.Signal transduction and targeted therapy · 2023Review
- Combination of an implantable defibrillator multi-sensor heart failure index and an apnea index for the prediction of atrial high-rate events.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Neurotrophins in the Neuropathophysiology, Course, and Complications of Obstructive Sleep Apnea-A Narrative Review.International journal of molecular sciences · 2023Review
- Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.JACC. Basic to translational science · 2022Review
- Role and mechanism of lncRNA under magnetic nanoparticles in atrial autonomic nerve remodeling during radiofrequency ablation of recurrent atrial fibrillation.Bioengineered · 2022Article
- The plasticity of cardiac sympathetic nerves and its clinical implication in cardiovascular disease.Frontiers in synaptic neuroscience · 2022Review
- Assessment of the Causal Effects of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study.Frontiers in cardiovascular medicine · 2022Article
- Obstructive Sleep Apnea and Cardiac Arrhythmias: A Contemporary Review.Journal of clinical medicine · 2021Review
- Predicting Incident Atrial Fibrillation Using Single Channel Nocturnal Oximetry: Can Necessity Become the Mother of Intervention?Annals of the American Thoracic Society · 2021Article
- Histopathological substrate of the atrial myocardium in the progression of obstructive sleep apnoea-related atrial fibrillation.Sleep & breathing = Schlaf & Atmung · 2021Article
- Sleep Apnea and Atrial Fibrillation: Role of the Cardiac Autonomic Nervous System.Methodist DeBakey cardiovascular journal · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms of atrial fibrillation (AF) induced by obstructive sleep apnea (OSA) are not completely understood. This study investigated the roles of the intrinsic and extrinsic cardiac autonomic nervous system in OSA-induced AF and provided noninvasive autonomic nervous modulation for the suppression of OSA-induced AF by using low-level transcutaneous electrical stimulation (LL-TS) of the auricular branch of the vagus nerve at the tragus. METHODS AND
resultsEighteen dogs received tracheostomy under general anesthesia and were randomly divided into 3 groups: the OSA group (OSA was simulated via clamping of the endotracheal tube at end expiration for 1.5 minutes every 10 minutes, n=6), the LL-TS + OSA group (simulated OSA plus LL-TS, at 80% of the slowing sinus rate, n=6), and the control group (sham surgery without stimulation, n=6). The effective refractory period was significantly shortened after 1 hour of simulated OSA, and the window of vulnerability and plasma norepinephrine levels were both markedly increased in the OSA group. OSA dramatically increased the neural function and activity of the intrinsic and extrinsic cardiac autonomic nervous system, including the superior left ganglionated plexus, the left stellate ganglion, and the left renal sympathetic nerve. OSA also significantly upregulated the expression levels of c-fos and nerve growth factor in the superior left ganglionated plexus and the left stellate ganglion. However, LL-TS markedly improved these parameters.
conclusionsThese findings suggest that the intrinsic and extrinsic cardiac autonomic nervous system plays crucial roles in the acute stage of OSA-induced AF. Noninvasive LL-TS suppressed shortening of atrial refractoriness and autonomic remodeling, which prevented OSA-induced AF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.