ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Obesity modulates diaphragm curvature in subjects with and without COPD.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Diaphragmatic overlay reconstruction using a bovine pericardial patch (Peri-Guard®): feasibility, safety, and radiographic outcomes.General thoracic and cardiovascular surgery · 2026Article
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- Geometric feature analysis for identifying and characterizing normal variations on chest radiographs.BMC medical imaging · 2026Article
- Body mass index-related heterogeneity in diaphragm thickening fraction response to exercise training in stable chronic obstructive pulmonary disease.Frontiers in physiology · 2026Article
- Diaphragmatic curvature analysis using dynamic digital radiography.European journal of radiology open · 2025Article
- Biomechanical implications of mass loading in a swine model of acute hypoxemic respiratory failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Analysis of risk factors and development of a predictive model for postoperative pulmonary complications in hepatic echinococcosis patients.Scientific reports · 2025Article
- Machine learning for detection of diffusion abnormalities-related respiratory changes among normal, overweight, and obese individuals based on BMI and pulmonary ventilation parameters: an observational study.BMC medical informatics and decision making · 2025Observational
- Integrated Lung, Diaphragm and Lower Limb Muscular Ultrasound: Clinical Correlations in Geriatric Patients with Acute Respiratory Illness.Diagnostics (Basel, Switzerland) · 2025Article
- Obesity and the Importance of Breathing.Cureus · 2025Review
- Electrical Impedance Tomography-Based Evaluation of Anesthesia-Induced Development of Atelectasis in Obese Patients.Journal of clinical medicine · 2024Article
- Diaphragm Ultrasound in Different Clinical Scenarios: A Review with a Focus on Older Patients.Geriatrics (Basel, Switzerland) · 2024Review
- Impact of obesity on double-lumen endobronchial tube displacement after lateral decubitus positioning.Korean journal of anesthesiology · 2023Article
- Factors Affecting Postoperative Lung Functions in Patients Undergoing Lobectomy for Non-Small Cell Lung Cancer.Medicina (Kaunas, Lithuania) · 2022Article
- Mortality and Exacerbation Risk by Body Mass Index in Patients with COPD in TIOSPIR and UPLIFT.Annals of the American Thoracic Society · 2022Article
- Perioperative Pulmonary Atelectasis: Part II. Clinical Implications.Anesthesiology · 2022Review
- Changes in Thoracic Cavity Volume After Bilateral Lung Transplantation.Frontiers in medicine · 2022Article
- Nonlinear relationship between visceral adiposity index and lung function: a population-based study.Respiratory research · 2021Article
- Visceral adiposity index is associated with lung function impairment: a population-based study.Respiratory research · 2021Article
- Pulmonary Function Influences the Performance of Berlin Questionnaire, Modified Berlin Questionnaire, and STOP-Bang Score for Screening Obstructive Sleep Apnea in Subjects with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a common comorbidity of chronic obstructive pulmonary disease (COPD) and has been associated with worse outcomes. However, it is unknown whether the interaction between obesity and COPD modulates diaphragm shape and consequently its function. The body mass index (BMI) has been used as a correlate of obesity. We tested the hypothesis that the shape of the diaphragm muscle and size of the ring of its insertion in non-COPD and COPD subjects are modulated by BMI. We recruited 48 COPD patients with postbronchiodilator forced expiratory volume in 1 s (FEV1)-to-forced vital capacity (FVC) < 0.7 and 29 age-matched smoker/exsmoker control (non-COPD) subjects, who underwent chest computed tomography (CT) at lung volumes ranging from functional residual capacity (FRC) to total lung capacity (TLC). We then computed maximum principal diaphragm curvature in the midcostal region of the left hemidiaphragm at the end of inspiration during quiet breathing (EI) and at TLC. The radius of maximum curvature of diaphragm muscle increased with BMI in both COPD and non-COPD subjects. The size of diaphragm ring of insertion on the chest wall also increased significantly with increasing BMI. Surprisingly, COPD severity did not appear to cause significant alteration in diaphragm shape except in normal-weight subjects at TLC. Our data uncovered important factors such as BMI, the size of the diaphragm ring of insertion, and disease severity that modulate the structure of the ventilatory pump in non-COPD and COPD subjects.
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