Evidence map›Paper›PMID 28903628›Full record

ArticleCulture, health & sexuality2018

What motivates serodiscordant couples to prevent HIV transmission within their relationships: findings from a PrEP implementation study in Kenya.

Rena C Patel, Anna M Leddy, Josephine Odoyo, Keerthana Anand, Gaelen Stanford-Moore, Imeldah Wakhungu, Elizabeth A Bukusi, Jared M Baeten, Joelle M Brown

Abstract read
In one paragraph

Article in Culture, health & sexuality, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Psychosocial support for HIV serodiscordant couples.Health psychology and behavioral medicine · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Living with Discordance: A Qualitative Description of the Challenges Faced by HIV Negative Married Women.International journal of community based nursing and midwifery · 2020
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rena C Patela Division of Allergy and Infectious Diseases, Department of Medicine , University of Washington , Seattle , WA , USA.ORCID 0000-0001-9893-5856
Anna M Leddyb Department of Health, Behavior and Society , Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.
Josephine Odoyoc Centre for Microbiologic Research , Kenya Medical Research Institute , Nairobi , Kenya.
Keerthana Anandd Center for Global Health Sciences , University of California , San Francisco , CA , USA.
Gaelen Stanford-Mooree School of Medicine , University of California , San Francisco , CA , USA.
Imeldah Wakhunguc Centre for Microbiologic Research , Kenya Medical Research Institute , Nairobi , Kenya.
Elizabeth A Bukusic Centre for Microbiologic Research , Kenya Medical Research Institute , Nairobi , Kenya.
Jared M Baeteng Departments of Epidemiology, Global Health, and Medicine , University of Washington , Seattle , WA , USA.
Joelle M Brownh Departments of Epidemiology and Biostatistics and Obstetrics, Gynecology, and Reproductive Sciences , University of California , San Francisco , CA , USA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
BIOLOGY OF INFECTIOUS DISEASES TRAINING PROGRAMT32AI007641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2000 to 2026
$6.9M
Optimizing Antiretroviral-Based HIV Prevention for HIV Serodiscordant CouplesR01MH095507 · NIMH · UNIVERSITY OF WASHINGTON · PI BAETEN, JARED · 2011 to 2020
$6.1M
Impact and Cost-effectiveness of Safer Conception Strategies for HIV PreventionK01MH100994 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BROWN, JOELLE MORGAN · 2013 to 2017
$893k
Investigating interactions between efavirenz-based antiretroviral therapy and contraceptive implantsK23AI120855 · NIAID · UNIVERSITY OF WASHINGTON · PI PATEL, RENA CHIMAN · 2015 to 2019
$850k
NCATS NIH HHS KL2 TR000143NIAID NIH HHS K23 AI120855NIAID NIH HHS P30 AI027757NIAID NIH HHS T32 AI007641NIMH NIH HHS K01 MH100994NIMH NIH HHS R01 MH095507
6 · The paper itself

Abstract

With the planned scale-up of pre-exposure prophylaxis (PrEP) for HIV prevention among serodiscordant couples in resource-limited settings, gaining an understanding of what motivates serodiscordant couples to prevent HIV is critical. We conducted 44 semi-structured, in-depth individual or couple interviews with 63 participants (33 HIV-infected and 30 HIV-uninfected participants) enrolled in a prospective implementation study of oral antiretroviral-based prevention in Kisumu, Kenya. Transcripts were iteratively analysed using inductive content analysis. Findings point to the importance of maintaining the emotional and economic stability of the partnership and family as motivators in preventing HIV transmission. Female participants identified fear of blame or potential violence for transmitting HIV as a motivator. Furthermore, couples primarily held the HIV-infected individual responsible for HIV prevention, but also held women more accountable for the use of prevention methods such as condoms. These themes substantiate traditional gender norms but also reveal how dyadic interdependence challenges these norms. As programmes in resource-limited settings scale up PrEP access, they should simultaneously capitalise on HIV serodiscordant couples' motivations for HIV prevention and address gender norms so women do not find themselves unduly responsible for the prevention of HIV transmission.

Indexed as

HIV SeropositivityMotivationAdultAnti-HIV AgentsFamily CharacteristicsFemaleHIV InfectionsHumansInterviews as TopicKenyaMalePre-Exposure ProphylaxisProspective StudiesSexual PartnersAnti-HIV Agentsgender normsHIV preventionKenyaMotivationsserodiscordant couples

Identifiers

PMID28903628
PMCPMC5851810

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.