ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Spontaneous Viral Load Decline and Subsequent Clearance of Chronic Hepatitis C Virus in Postpartum Women Correlates With Favorable Interleukin-28B Gene Allele.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Correlation between IL-28 polymorphism and spontaneous clearance in HCV patients: systematic review and meta-analysis.Archives of virology · 2021Pooled it
- CD4+ T cell restoration and control of hepatitis C virus replication after childbirth.The Journal of clinical investigation · 2020Trial
- Anellovirus constraint from 2 to 6 months postpartum followed by betatorquevirus and gammatorquevirus dominance in serum and milk.Journal of virology · 2025Article
- Viral hepatitis in pregnancy.Journal of viral hepatitis · 2022Review
- Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain.Infection and drug resistance · 2022Article
- Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review.JNMA; journal of the Nepal Medical Association · 2021Review
- Lymphocyte Landscape after ChronicInternational journal of molecular sciences · 2020Review
- The Ethics of Precision Rationing: Human Genetics and the Need for Debate on Stratifying Access to Medication.Public health genomics · 2020Article
- Testing for Hepatitis C in Pregnancy: the Time has Come for Routine Rather than Risk-based.Current hepatology reports · 2019Article
- Spontaneous Clearance of Chronic HCV: The Key Ending Left in the Dark.Open access Macedonian journal of medical sciences · 2019Article
- Hepatitis C virus infection in mothers and children.Canadian liver journal · 2019Article
- Hepatitis C in Pregnancy: A Unique Opportunity to Improve the Hepatitis C Cascade of Care.Hepatology communications · 2019Review
- Direct-Acting Antivirals and Hepatitis C: The Ethics of Price and Rationing by Genotype.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Treatment of Hepatitis C during Pregnancy-Weighing the Risks and Benefits in Contrast to HIV.Current HIV/AIDS reports · 2018Review
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9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostpartum hepatitis C viral (HCV) load decline followed by spontaneous clearance has been previously described. Herein we identify predictors for viral decline in a cohort of HCV-infected postpartum women.
methodsPregnant women at Cairo University were screened for anti-HCV antibodies and HCV RNA, and viremic women were tested for quantitative HCV RNA at 3, 6, 9, and 12 months postpartum. Spontaneous clearance was defined as undetectable viremia twice at least 6-months apart. Associations between viral load and demographic, obstetrical, HCV risk factors, and interleukin-28B gene (IL28B) polymorphism (rs12979860) were assessed.
resultsOf 2514 women, 97 (3.9%) had anti-HCV antibodies, 54 (2.1%) were viremic and of those, 52 (2.1%) agreed to IL28B testing. From pregnancy until 12 months postpartum, IL28B-CC allele women had a significant viral decline (P = .009). After adjusting, the IL28B-CC allele had a near significant difference compared to the CT allele (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.75,1.00; P = .05), but not the TT allele (OR, 0.91; 95% CI, 0.61,1.38; P = .64). All 14/52 (26.9%) women who subsequently cleared were among the 15 with undetectable viremia at 12 months, making that time point a strong predictor of subsequent clearance (sensitivity = 100%, specificity = 97.4%, positive predictive value = 93.3%, negative predictive value = 100%).
conclusionsIL28B-CC genotype and 12-month postpartum undetectable viremia were the best predictors for viral decline and subsequent clearance. These 2 predictors should influence clinical decision making.
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