ArticleToxicological sciences : an official journal of the Society of Toxicology2017
RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Cell composition, transcriptomic, and functional pathway changes in the hippocampus in Alzheimer's disease and overlap with lead (Pb) exposure signatures.medRxiv : the preprint server for health sciences · 2026Article
- Evidence for Genotype-Specific Optimal Blood Lead Levels for Cancer Risk:International journal of molecular sciences · 2026Article
- Impact of intermittent lead exposure on hominid brain evolution.Science advances · 2025Article
- Single-cell investigation of lead toxicity from neurodevelopment to neurodegeneration: Current review and future opportunities.Current opinion in toxicology · 2024Article
- [Application of multiomics mass spectrometry in the research of chemical exposome].Se pu = Chinese journal of chromatography · 2024Review
- Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics.Scientific reports · 2023Article
- Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment.Scientific reports · 2022Article
- Impact of environmental neurotoxic: current methods and usefulness of human stem cells.Heliyon · 2020Review
- Single-Cell Analysis of the Gene Expression Effects of Developmental Lead (Pb) Exposure on the Mouse Hippocampus.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Alternative splicing is highly variable among Daphnia pulex lineages in response to acute copper exposure.BMC genomics · 2020Article
- TimeMeter assesses temporal gene expression similarity and identifies differentially progressing genes.Nucleic acids research · 2020Article
- Systems Biology-Based Analysis Indicates Global Transcriptional Impairment in Lead-Treated Human Neural Progenitor Cells.Frontiers in genetics · 2019Article
- A Novel Approach to Single Cell RNA-Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell-Derived Retinal Cell Types.Stem cells (Dayton, Ohio) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Lead (Pb) is a well-known toxicant, especially for the developing nervous system, albeit the mechanism is largely unknown. In this study, we use time series RNA-seq to conduct a genome-wide survey of the transcriptome response of human embryonic stem cell-derived neural progenitor cells to lead treatment. Using a dynamic time warping algorithm coupled with statistical tests, we find that lead can either accelerate or decelerate the expression of specific genes during the time series. We further show that lead disrupts a neuron- and brain-specific splicing factor NOVA1 regulated splicing network. Using lead induced transcriptome change signatures, we predict several known and novel disease risks under lead exposure. The findings in this study will allow a better understanding of the mechanism of lead toxicity, facilitate the development of diagnostic biomarkers and treatment for lead exposure, and comprise a highly valuable resource for environmental toxicology. Our study also demonstrates that a human (embryonic stem) cell-derived system can be used for studying the mechanism of toxicants, which can be useful for drug or compound toxicity screens and safety assessment.
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Registered trials
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