ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2017
Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Effects of vitamin D on insulin resistance and fasting blood glucose in pregnant women with insufficient or deficient vitamin D: a randomized, placebo-controlled trial.BMC endocrine disorders · 2022Trial
- Review
- Timing over Dose: Maternal Vitamin D, Periconceptional Window, and Early-Life Respiratory Programming.Nutrients · 2026Review
- Review
- Understanding the role of immune-mediated inflammatory disease related cytokines interleukin 17 and 23 in pregnancy: A systematic review.Journal of translational autoimmunity · 2025Review
- The Role of Vitamin D Metabolism-Related Genes in Recurrent Pregnancy Loss and Their Immune Microenvironmental Changes.Journal of multidisciplinary healthcare · 2025Article
- Review
- Study on the immunomodulatory mechanism of vitamin D in patients with unexplained recurrent spontaneous abortion.Heliyon · 2024Article
- No evidence of a causal relationship between miscarriage and 25-hydroxyvitamin D: a Mendelian randomization study.Human reproduction open · 2024Article
- Article
- Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box.Journal of clinical medicine · 2023Review
- Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage.Journal of clinical medicine · 2022Article
- IL-23 Inhibits Trophoblast Proliferation, Migration, and EMT via Activating p38 MAPK Signaling Pathway to Promote Recurrent Spontaneous Abortion.Journal of microbiology and biotechnology · 2022Article
- Effect of Vitamin D Supplementation on the Cerebral Placental Ratio in Pregnancy Complicated with Early Fetal Growth Restriction.Journal of clinical medicine · 2022Article
- Evaluating Vitamin D and foxp3 mRNA levels in women with recurrent spontaneous abortion.JBRA assisted reproduction · 2022Article
- The Role of Immune Cells in Recurrent Spontaneous Abortion.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- SNP rs12794714 of CYP2R1 is associated with serum vitamin D levels and recurrent spontaneous abortion (RSA): a case-control study.Archives of gynecology and obstetrics · 2021Article
- A novel update on vitamin D in recurrent pregnancy loss (Review).Molecular medicine reports · 2021Review
- Vitamin D receptor gene polymorphisms and haplotypes in the etiology of recurrent miscarriages.Scientific reports · 2021Article
- Review
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunological mechanisms have been proposed to underlie the pathogenesis of recurrent spontaneous abortion (RSA). Vitamin D has a potent immunomodulatory effect, which may affect pregnancy outcome. The objective of this study was to investigate 25-hydroxyvitamin D [25(OH) D] concentration and vitamin D receptor (VDR) expression in the decidual tissues of RSA patients. Thirty women with RSA (RSA group) and thirty women undergoing elective abortion (control group) were recruited during 2016 from gynecology outpatient clinics. We measured 25(OH) D, interleukin (IL)-17, IL-23, transforming growth factor β (TGF-β), VDR and 1-α-hydroxylase (CYP27B1) in decidual tissues collected during the abortion procedure. In the RSA group, 25(OH) D and TGF-β were significantly decreased while IL-17 and IL-23 were significantly increased compared with the control group. VDR expression was significantly decreased in the RSA group compared with the control group. Logistic regression analysis showed a significant negative correlation between 25(OH) D in decidual tissues and RSA. These results indicated that vitamin D concentrations in the decidua are associated with inflammatory cytokine production, suggesting that vitamin D and VDR may play a role in the etiology of RSA.
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