Evidence map›Paper›PMID 28902899›Full record

ArticlePloS one2017

Selective autonomic stimulation of the AV node fat pad to control rapid post-operative atrial arrhythmias.

Marco A Mercader, Dingchao He, Aditya C Sharma, Mark C Marchitto, Gregory Trachiotis, Gene A Bornzin, Richard Jonas, Jeffrey P Moak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marco A MercaderDepartment of Medicine, Division of Cardiology, George Washington University, Washington, D.C., United States of America.ORCID http://orcid.org/0000-0001-6723-570X
Dingchao HeDepartment of Surgery, Division of Cardiac Surgery, Children's National Health System, Washington, D.C., United States of America.
Aditya C SharmaDepartment of Medicine, Division of Cardiology, George Washington University, Washington, D.C., United States of America.
Mark C MarchittoSchool of Medicine, George Washington University, Washington, D.C., United States of America.
Gregory TrachiotisDepartment of Surgery, Division of Cardiothoracic Surgery, George Washington University, Washington, D.C., United States of America.
Gene A BornzinImplantable Electronic Systems Division (IESD), St. Jude Medical, Sylmar, California, United States of America.
Richard JonasDepartment of Surgery, Division of Cardiac Surgery, Children's National Health System, Washington, D.C., United States of America.
Jeffrey P MoakDepartment of Pediatrics, Division of Cardiology, Children's National Health System, Washington, D.C., United States of America.
George Washington University · USChildren's National · USSt. Jude Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Junctional ectopic tachycardia (JET) and atrial fibrillation (AF) occur in patients recovering from open-heart surgery (OHS). Pharmacologic treatment is used for the control of post-operative atrial arrhythmias (POAA), but is associated with side effects. There is a need for a reversible, modulated solution to rate control. We propose a non-pharmacologic technique that can modulate AV nodal conduction in a selective fashion. Ten mongrel dogs underwent OHS. Stimulation of the anterior right (AR) and inferior right (IR) fat pad (FP) was done using a 7-pole electrode. The IR was more effective in slowing the ventricular rate (VR) to AF (52 +/- 20 vs. 15 +/- 10%, p = 0.003) and JET (12 +/- 7 vs. 0 +/- 0%, p = 0.02). Selective site stimulation within a FP region could augment the effect of stimulation during AF (57 +/- 20% (maximum effect) vs. 0 +/- 0% (minimum effect), p<0.001). FP stimulation at increasing stimulation voltage (SV) demonstrated a voltage-dependent effect (8 +/- 14% (low V) vs. 63 +/- 17 (high V) %, p<0.001). In summary, AV node fat pad stimulation had a selective effect on the AV node by decreasing AV nodal conduction, with little effect on atrial activity.

Indexed as

Adipose TissueAnimalsAtrial FibrillationAtrioventricular NodeAutonomic Nervous SystemCardiac Pacing, ArtificialCardiac Surgical ProceduresDisease Models, AnimalDogsElectric Stimulation TherapyElectrocardiographyFemaleHeart Conduction SystemHeart RateHumansMale

Identifiers

PMID28902899
PMCPMC5597131
OpenAlexW4240290084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.