Evidence map›Paper›PMID 28902283›Full record

ArticleMemorias do Instituto Oswaldo Cruz2017

New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study.

Adrian Man, Cristina Nicoleta Ciurea, Dan Pasaroiu, Ana-Ioana Savin, Felicia Toma, Floredana Sular, Luigi Santacroce, Anca Mare

Abstract read
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Evaluating the Role ofInterdisciplinary perspectives on infectious diseases · 2025
    Review
  6. A Bird's-Eye View of the Pathophysiologic Role of the Human Urobiota in Health and Disease: Can We Modulate It?Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  7. Oral microbiota in human health and disease: A perspective.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Association of Vitamins D, BFood technology and biotechnology · 2022
    Article
  14. Review
  15. Article
  16. Journal of fungi (Basel, Switzerland) · 2021
    Review
  17. Observational
  18. Article
  19. Potential Pathogenicity ofBioMed research international · 2021
    Article
  20. Microorganisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adrian ManUniversity of Medicine and Pharmacy, Department of Microbiology, Tîrgu Mures, Romania.
Cristina Nicoleta CiureaUniversity of Medicine and Pharmacy, Tîrgu Mures, Romania.
Dan PasaroiuUniversity of Medicine and Pharmacy, Tîrgu Mures, Romania.
Ana-Ioana SavinUniversity of Medicine and Pharmacy, Tîrgu Mures, Romania.
Felicia TomaUniversity of Medicine and Pharmacy, Department of Microbiology, Tîrgu Mures, Romania.
Floredana SularUniversity of Medicine and Pharmacy, Department of Laboratory Medicine, Tîrgu Mures, Romania.
Luigi SantacroceUniversity of Bari Aldo Moro, Policlinico University Hospital, Ionian Department and Microbiology and Virology Service, Bari, Italy.
Anca MareUniversity of Medicine and Pharmacy, Department of Microbiology, Tîrgu Mures, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated.

objectivesThe purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients.

methodsThe effects of different concentrations of glucose and fructose (1000 mg%, 500 mg%, 250 mg% and 100 mg% w/v) on the growth rate of CA have been studied by flow-cytometry.

findingsWe found that glucose concentration is directly related to CA growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients; we also show that fructose inhibits CA growth rate. MAIN

conclusionsAs a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites.

Indexed as

Candida albicansDiabetes MellitusFlow CytometryFructoseGlucoseHumansIn Vitro TechniquesTime FactorsFructoseGlucose

Identifiers

PMID28902283
PMCPMC5572443

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.