Evidence map›Paper›PMID 28902151›Full record

ArticleMarine drugs2017

APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel K

Lien Moreels, Steve Peigneur, Diogo T Galan, Edwin De Pauw, Lászlo Béress, Etienne Waelkens, Luis A Pardo, Loïc Quinton, Jan Tytgat

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Crude Venom from Sea AnemoneMarine drugs · 2026
    Article
  4. Sea AnemoneMarine drugs · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lien MoreelsToxicology and Pharmacology, KU Leuven, Leuven 3000, Belgium. lien.moreels@kuleuven.be.ORCID 0000-0002-7173-7195
Steve PeigneurToxicology and Pharmacology, KU Leuven, Leuven 3000, Belgium. steve.peigneur@kuleuven.be.
Diogo T GalanToxicology and Pharmacology, KU Leuven, Leuven 3000, Belgium. diogo.teodorogalan@kuleuven.be.
Edwin De PauwLaboratory of Mass Spectrometry-MolSys, University of Liege, Liege 4000, Belgium. e.depauw@ulg.ac.be.
Lászlo BéressImmunology and Rheumatology, Section of Peptide Chemistry, Hannover Medical School (MHH), Hannover 30625, Germany. dr.beress@t-online.de.
Etienne WaelkensLaboratory of Protein Phosphorylation and Proteomics, KU Leuven, Leuven 3000, Belgium. etienne.waelkens@kuleuven.be.
Luis A PardoOncophysiology Group, Max Planck Institute for Experimental Medicine; Göttingen 37075, Germany. pardo@em.mpg.de.ORCID 0000-0003-1375-4349
Loïc QuintonLaboratory of Mass Spectrometry-MolSys, University of Liege, Liege 4000, Belgium. loic.quinton@ulg.ac.be.
Jan TytgatToxicology and Pharmacology, KU Leuven, Leuven 3000, Belgium. jan.tytgat@kuleuven.be.
KU Leuven · BEUniversity of Liège · BEMax Planck Institute of Experimental Medicine · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human ether-à-go-go channel (hEag1 or K

Indexed as

Sea AnemonesAnimalsAntineoplastic AgentsCell Line, TumorCnidarian VenomsInhibitory Concentration 50OocytesPotassium Channels, Voltage-GatedToxins, BiologicalXenopusAntineoplastic AgentsCnidarian VenomsPotassium Channels, Voltage-GatedToxins, BiologicalAPETxcancerKV10.1potassium channelsea anemone peptide

Identifiers

PMID28902151
PMCPMC5618426
OpenAlexW2753972346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.