Evidence map›Paper›PMID 28901838›Full record

ArticleArchives of environmental & occupational health2018

Investigation of associations between exposures to pesticides and testosterone levels in Thai farmers.

Parinya Panuwet, Chandresh Ladva, Dana Boyd Barr, Tippawan Prapamontol, John D Meeker, Priya Esilda D'Souza, Héctor Maldonado, P Barry Ryan, Mark G Robson

Abstract read
In one paragraph

Article in Archives of environmental & occupational health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Parinya Panuweta Department of Environmental Health , Rollins School of Public Health, Emory University , Atlanta , Georgia , USA.
Chandresh Ladvaa Department of Environmental Health , Rollins School of Public Health, Emory University , Atlanta , Georgia , USA.
Dana Boyd Barra Department of Environmental Health , Rollins School of Public Health, Emory University , Atlanta , Georgia , USA.
Tippawan Prapamontolb Pollution and Environmental Health Research, Research Institute for Health Sciences, Chiang Mai University , Chiang Mai , Thailand.
John D Meekerc Environmental Health Sciences, School of Public Health, University of Michigan , Ann Arbor , Michigan , USA.
Priya Esilda D'Souzaa Department of Environmental Health , Rollins School of Public Health, Emory University , Atlanta , Georgia , USA.
Héctor Maldonadod Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University , New Brunswick , New Jersey , USA.
P Barry Ryana Department of Environmental Health , Rollins School of Public Health, Emory University , Atlanta , Georgia , USA.
Mark G Robsond Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University , New Brunswick , New Jersey , USA.
Emory University · USRutgers, The State University of New Jersey · USChiang Mai University · THUniversity of Michigan–Ann Arbor · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ROBERT John LAUMBACH · 1988 to 2026
$47.4M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Impact of prenatal insecticide exposure on neurodevelopmental trajectories in a Thai birth cohort: building exposure science and neurodevelopmental research capacity in ThailandR01ES026082 · NIEHS · EMORY UNIVERSITY · PI BARR, DANA BOYD, FIEDLER, NANCY L · 2016 to 2020
$3.1M
Respiratory, reproductive, and other effects of air pollution and high altitudeD43TW005746 · FIC · EMORY UNIVERSITY · PI STEENLAND, NELSON K · 2001 to 2012
$1.9M
Thai Fogarty ITREOH CenterD43TW007849 · FIC · UNIV OF MED/DENT NJ-SCH OF PUBLIC HEALTH · PI ROBSON, MARK GREGORY · 2007 to 2011
$725k
Early Pesticide Exposure and Neurodevelopmental Outcomes in a Thai Birth CohortR21ES015465 · NIEHS · EMORY UNIVERSITY · PI RYAN, P. BARRY · 2009 to 2010
$276k
FIC NIH HHS D43 TW005746FIC NIH HHS D43 TW007849NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES026082NIEHS NIH HHS R21 ES015465
6 · The paper itself

Abstract

We conducted a cross-sectional study to assess the relationship between pesticide exposures and testosterone levels in 133 male Thai farmers. Urine and serum samples were collected concurrently from participants. Urine was analyzed for levels of specific and nonspecific metabolites of organophosphates (OPs), pyrethroids, select herbicides, and fungicides. Serum was analyzed for total and free testosterone. Linear regression analyses revealed significant negative relationships between total testosterone and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) after controlling for covariates (eg, age, BMI, smoking status). Positive significant associations were found between some OP pesticides and total testosterone. Due to the small sample size and the observational nature of the study, future investigation is needed to confirm our results and to elucidate the biological mechanisms.

Indexed as

AdultChromatography, GasChromatography, High Pressure LiquidCross-Sectional StudiesFarmersFungicides, IndustrialGas Chromatography-Mass SpectrometryHerbicidesHumansInsecticidesMaleMiddle AgedOccupational ExposureOrganophosphatesPyrethrinsTandem Mass SpectrometryFungicides, IndustrialHerbicidesInsecticidesOrganophosphatesPyrethrinsTestosteroneEndocrine disruptorexposuresfarmerspesticidesreproductive healthtestosterone

Identifiers

PMID28901838
PMCPMC6422528
OpenAlexW2756023964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.