Evidence map›Paper›PMID 28901583›Full record

ArticleProteins2018

Improved protein contact predictions with the MetaPSICOV2 server in CASP12.

Daniel W A Buchan, David T Jones

Abstract read
In one paragraph

Article in Proteins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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  6. Using metagenomic data to boost protein structure prediction and discovery.Computational and structural biotechnology journal · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel W A BuchanDepartment of Computer Science, University College London, London, UK.ORCID 0000-0001-7391-4696
David T JonesDepartment of Computer Science, University College London, London, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/M011712/1
6 · The paper itself

Abstract

In this paper, we present the results for the MetaPSICOV2 contact prediction server in the CASP12 community experiment (http://predictioncenter.org). Over the 35 assessed Free Modelling target domains the MetaPSICOV2 server achieved a mean precision of 43.27%, a substantial increase relative to the server's performance in the CASP11 experiment. In the following paper, we discuss improvements to the MetaPSICOV2 server, covering both changes to the neural network and attempts to integrate contact predictions on a domain basis into the prediction pipeline. We also discuss some limitations in the CASP12 assessment which may have overestimated the performance of our method.

Indexed as

InternetMachine LearningModels, MolecularNeural Networks, ComputerProtein ConformationAlgorithmsComputational BiologyCrystallography, X-RayHumansProtein Interaction Domains and MotifsProteinsSoftwareProteinsbioinformaticscontact predictionmachine learningmeta-prediction

Identifiers

PMID28901583
PMCPMC5836854

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.