ArticleMolecular medicine reports2017
Ailanthone induces G2/M cell cycle arrest and apoptosis of SGC‑7901 human gastric cancer cells.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Plant-Derived Diterpenoids as Potential Chemotherapeutics for Gastric Cancer.Current oncology reports · 2026Review
- Ailanthone restrains hepatocellular carcinoma progression by inducing ferroptosis and disrupting mitochondrial homeostasis.Scientific reports · 2025Article
- Quassinoids as Promising Anti-cancer Agents.Current medicinal chemistry · 2025Review
- In Vitro Screening of Ecotoxic and Cytotoxic Activities ofInternational journal of molecular sciences · 2024Article
- Ailanthone synergizes with PARP1 inhibitor in tumour growth inhibition through crosstalk of DNA repair pathways in gastric cancer.Journal of cellular and molecular medicine · 2024Article
- Elucidation of the mechanism of action of ailanthone in the treatment of colorectal cancer: integration of network pharmacology, bioinformatics analysis and experimental validation.Frontiers in pharmacology · 2024Article
- Ailanthone suppresses the activity of human colorectal cancer cells through the STAT3 signaling pathway.International journal of molecular medicine · 2022Article
- Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.Frontiers in oncology · 2022Article
- Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role.Antioxidants (Basel, Switzerland) · 2021Review
- A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity.Computational and structural biotechnology journal · 2021Article
- Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition.Frontiers in oncology · 2021Article
- Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.International journal of biological sciences · 2021Article
- Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.Journal of medicinal chemistry · 2020Article
- Ailanthone: A novel potential drug for treating human cancer.Oncology letters · 2020Review
- Effects of an ethyl acetate extract of Daphne altaica stem bark on the cell cycle, apoptosis and expression of PPARγ in Eca‑109 human esophageal carcinoma cells.Molecular medicine reports · 2020Article
- Ailanthone Induces Cell Cycle Arrest and Apoptosis in Melanoma B16 and A375 Cells.Biomolecules · 2019Article
- Mechanisms Underlying Therapeutic Effects Of Traditional Chinese Medicine On Gastric Cancer.Cancer management and research · 2019Article
- Bioactive Ingredients in Chinese Herbal Medicines That Target Non-coding RNAs: Promising New Choices for Disease Treatment.Frontiers in pharmacology · 2019Review
- Ailanthone Promotes Human Vestibular Schwannoma Cell Apoptosis and Autophagy by Downregulation of miR-21.Oncology research · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ailanthone is a major quassinoid extracted from the Chinese medicinal herb Ailanthus altissima, which has been reported to exert antiproliferative effects on various cancer cells. The present study aimed to investigate the antitumor effects of ailanthone on SGC‑7901 cells, and to analyze its underlying molecular mechanisms. Following treatment with ailanthone, Cell Counting kit‑8 was used to detect the cytotoxic effects of ailanthone on SGC‑7901 cells in vitro. The typical apoptotic morphology of SGC‑7901 cells was observed by Hoechst 33258 staining. Cell cycle progression and apoptosis were measured by flow cytometry, and the protein and mRNA expression levels of Bcl‑2 and Bax were analyzed by western blot analysis and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) respectively, in SGC‑7901 cells. The results of the present study indicated that ailanthone inhibited the proliferation of SGC‑7901 cells in a dose‑ and time‑dependent manner in vitro, and also demonstrated that ailanthone induced G2/M phase cell cycle arrest and apoptosis of SGC‑7901 cells. Furthermore, analysis of the underlying molecular mechanisms revealed that ailanthone downregulated the expression levels of Bcl‑2, whereas the expression levels of Bax were upregulated at the protein and mRNA levels. In conclusion, ailanthone may inhibit the proliferation of SGC‑7901 cells by inducing G2/M phase cell cycle arrest and apoptosis via altering the protein and mRNA expression levels of Bcl‑2 and Bax in SGC‑7901 cells.
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