ArticleMolecular medicine reports2017
Taurine alleviates lipopolysaccharide‑induced liver injury by anti‑inflammation and antioxidants in rats.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 73 citations in OpenAlex.
- Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study.BMC oral health · 2025Trial
- Taurine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting NF-κB Pathway-Mediated Inflammation, Mitochondrial Dysfunction, and Apoptosis.Cardiovascular toxicology · 2026Article
- Protective effects of taurine against chemical and natural compound-induced toxicity: mechanistic insights and therapeutic potential.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Surgery and Acute Stress Decrease NRF2 mRNA Expression and Promote Iron Metabolism Alteration, Oxidative Stress, and Inflammatory Gene Expression in the Liver of Prehypertensive Rats.Physiological research · 2025Article
- Taurine Protects Against Melamine-Induced Hippocampal Neurotoxicity in Rats by Attenuating Metabolic Responses, Autophagy and Inflammation.Neurotoxicity research · 2025Article
- A modified hot phenol-based protocol for high-purity Escherichia coli lipopolysaccharide extraction: Biochemical validation, stem cell cytotoxicity, and dose dependent multi-organ inflammation in a rat model.Biotechnology reports (Amsterdam, Netherlands) · 2025Article
- The Hepatoprotective Properties of the Revised Formulation of Dahuang Xiaoshi Tang, an Ancient Chinese Herbal Decoction, Are Probed by Integrated Metabolomics and Network Pharmacology.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Effects of Rumen-Protected Taurine Supplementation on Ruminal Fermentation, Hematological Profiles, Liver Function, and Immune Responses in Yaks.Animals : an open access journal from MDPI · 2025Article
- Taurine Mitigates Metaflumizone-Induced Hepatonephrotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation, and Apoptosis.Journal of biochemical and molecular toxicology · 2025Article
- Palliative effect of taurine against hepatic injury induced by polystyrene microplastics through antioxidant and metabolic pathway modulation in mice.Frontiers in pharmacology · 2025Article
- Theranostic Applications of Taurine-Derived Carbon Dots in Colorectal Cancer: Ferroptosis Induction and Multifaceted Antitumor Mechanisms.International journal of nanomedicine · 2025Article
- Alleviation of taurine on liver injury of type 2 diabetic rats by improving antioxidant and anti-inflammatory capacity.Heliyon · 2024Article
- Article
- Effects of dietary rumen-protected glucose level and taurine supplementation on weight change and oxidative stress state of yaks after transport.Frontiers in veterinary science · 2024Article
- A Key Metabolic Regulator of Bone and Cartilage Health.Endocrinology and metabolism (Seoul, Korea) · 2022Review
- Article
- Correlation Analysis of Umbilical Cord Blood Metabolic Phenotype and Inflammation in Patients with Gestational Diabetes Mellitus Complicated with Overweight and Obesity.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway.Frontiers in bioengineering and biotechnology · 2022Article
- Effect of taurine in muscle damage markers and inflammatory cytokines in running exercise.Frontiers in physiology · 2022Article
- Inhibitory effect of taurine on rotator cuff degeneration via mitochondrial protection.American journal of translational research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the protective effect of taurine on lipopolysaccharide (LPS)‑induced liver injury and its mechanisms. Male rats were randomly divided into three groups: Normal saline, LPS model and taurine treatment. Experimental animals were treated with saline or taurine (dissolved in saline, 200 mg/kg/day) via intravenous injection. After 2 h, saline or LPS (0.5 mg/kg) was administrated via intraperitoneal injection. Markers of liver injury, pro‑inflammatory cytokines and superoxide dismutase (SOD) activity were determined in plasma. Liver tissues were removed for morphological analysis and determination by western blot analysis. Taurine significantly reduced the elevation in the levels of LPS‑induced aspartate transaminase and alanine transaminase and decreased the concentrations of LPS‑induced inflammatory factors including tumor necrosis factor‑α and interleukin‑6. Taurine also increased the activity of SOD in serum and the expression of heme oxygenase‑1 protein in liver tissue. Taurine pretreatment also reduced the elevated expression levels of LPS‑induced cyclooxygenase‑2, nuclear factor κB and extracellular regulated protein kinase. The results from the present study demonstrated that taurine alleviates LPS‑induced liver injury. The beneficial role of taurine may be associated with its reduction of pro‑inflammatory response and oxidative stress.
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