ArticleInternational journal of molecular medicine2017
Negative pressure wound therapy: Regulating blood flow perfusion and microvessel maturation through microvascular pericytes.
Article in International journal of molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04455724 (Negative Pressure Incisional Wound Therapy for High-risk Ventral Hernia Repair), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Negative Pressure Incisional Wound Therapy for High-risk Ventral Hernia Repair: a Randomized Controlled Trial
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Negative Pressure Therapy in Diabetic Foot Ulcer: A Meta-Analysis.Journal of diabetes · 2026Pooled it
- Update on therapeutic strategy for esophageal anastomotic leak: A systematic literature review.Thoracic cancer · 2023Pooled it
- Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis.Journal of advanced research · 2026Article
- Advances in diabetic wound healing: from pathophysiology to emerging therapies.Acta diabetologica · 2026Review
- The role of negative pressure wound therapy-From the perspective of drainage fluid composition.Surgery open science · 2026Article
- Negative-Pressure Induces Epithelial-Mesenchymal Transition via Thrombospondin-1 Upregulation in Intact Diabetic Skin.International wound journal · 2026Article
- A cross-specialty, evidence-based Delphi consensus of a care bundle to reduce surgical site infections.International journal of surgery (London, England) · 2026Article
- Effective management of cervical anastomotic leakage post-esophageal cancer surgery using negative pressure wound therapy with saline instillation: A case report.Asia-Pacific journal of oncology nursing · 2025Article
- Comparison and evaluation of negative pressure wound therapy versus standard wound care in the treatment of diabetic foot ulcers.BMC surgery · 2025Article
- Negative Pressure Wound Therapy-A Vacuum-Mediated Positive Pressure Wound Therapy and a Closer Look at the Role of the Laser Doppler.Journal of clinical medicine · 2024Article
- Effects of endoluminal vacuum sponge therapy on the perfusion of gastric conduit in a porcine model for esophagectomy.Surgical endoscopy · 2024Article
- The feasibility of negative pressure wound therapy versus standard dressings in paediatric hand and foot burns protocol: a pilot, single-centre, randomised control trial.Pilot and feasibility studies · 2023Article
- Article
- Autologous wound margin point columnar full-thickness skin grafting combined with negative pressure wound therapy improves wound healing in refractory diabetic foot ulcers.International wound journal · 2023Article
- Negative-Pressure Wound Therapy: What We Know and What We Need to Know.Advances in experimental medicine and biology · 2023Article
- The GPI-Anchored Protein Thy-1/CD90 Promotes Wound Healing upon Injury to the Skin by Enhancing Skin Perfusion.International journal of molecular sciences · 2022Article
- [Feasibility study on the preparation of novel negative pressure materials for constructing new matrix of full-thickness skin defect wounds in rats].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Circular RNA expression profiles following negative pressure wound therapy in burn wounds with experimentalBioengineered · 2022Article
- Efficacy of Prophylactic Negative-Pressure Wound Therapy with Delayed Primary Closure for Contaminated Abdominal Wounds.Surgery research and practice · 2022Article
- Combined administration of laminin-221 and prostacyclin agonist enhances endogenous cardiac repair in an acute infarct rat heart.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Negative pressure wound therapy (NPWT) has been demonstrated to accelerate wound healing by promoting angiogenesis. However, whether blood flow perfusion is regulated by microvessel maturation and pericytes following NPWT remains unclear, as well as the exact association between pericytes and collagen type IV. The aim of this study was to investigate the relevant association between blood flow perfusion and microvessel maturation and pericytes following NPWT, and to further explore the underlying molecular mechanisms. We also aimed to investigate the association between pericytes and collagen type IV. For this purpose, we created a rat model of diabetic wounds and microvascular blood flow perfusion was detected using a laser Doppler blood perfusion imager. The expression levels of angiogenin-1, tyrosine phosphorylation of tyrosine kinase receptor-2 (Tie-2), α-smooth muscle actin (α-SMA) and collagen type IV were detected and analyzed through immunohistochemistry, immunofluorescence, RT-qPCR and western blot analysis. The results revealed that NPWT promoted the overexpression of angiogenin-1, Tie-2, α-SMA and collagen type IV, and significantly increased blood flow perfusion coupled with microvessel maturation in the NPWT group at the later stages (7-10 days) of wound healing. Our results suggested that NPWT can preferentially enhance vessel maturation and increase the number of pericytes, thus regulating blood flow perfusion. On the other hand, pericytes and collagen type IV had a mutual interaction, promoting microvessel maturation.
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