Trial reportEuropean journal of clinical nutrition2018
A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women.
Trial report in European journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The effect of sodium restriction on iodine prophylaxis: a review.Journal of endocrinological investigation · 2022Pooled it
- Pooled it
- Randomised controlled trial of lifestyle interventions for abdominal obesity in primary health care.Primary health care research & development · 2024Trial
- Thyroid function and iodine intake: global recommendations and relevant dietary trends.Nature reviews. Endocrinology · 2024Review
- Iodine and plant-based diets: a narrative review and calculation of iodine content.The British journal of nutrition · 2024Review
- Effect of a Modern Palaeolithic Diet in Combination with a Sprint Interval Training on Metabolic and Performance-Related Parameters in Male Athletes: A Pilot Trial.Nutrition and metabolic insights · 2024Article
- Urinary iodine excretion and optimal time point for sampling when estimating 24-h urinary iodine.The British journal of nutrition · 2023Article
- The Relationship between Gastrointestinal Health, Micronutrient Concentrations, and Autoimmunity: A Focus on the Thyroid.Nutrients · 2022Review
- The Prevalence and Risk Factors Associated with Iodine Deficiency in Canadian Adults.Nutrients · 2022Article
- Article
- Is There an Ideal Diet to Protect against Iodine Deficiency?Nutrients · 2021Review
- A Clinical Perspective of Low Carbohydrate Ketogenic Diets: A Narrative Review.Frontiers in nutrition · 2021Review
- Carbohydrate knowledge, dietary guideline awareness, motivations and beliefs underlying low-carbohydrate dietary behaviours.Scientific reports · 2020Article
- Long-term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations.European journal of nutrition · 2020Article
- Article
- Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic.Nutrients · 2019Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesDifferent diets are used for weight loss. A Paleolithic-type diet (PD) has beneficial metabolic effects, but two of the largest iodine sources, table salt and dairy products, are excluded. The objectives of this study were to compare 24-h urinary iodine concentration (24-UIC) in subjects on PD with 24-UIC in subjects on a diet according to the Nordic Nutrition Recommendations (NNR) and to study if PD results in a higher risk of developing iodine deficiency (ID), than NNR diet. SUBJECTS/
methodsA 2-year prospective randomized trial in a tertiary referral center where healthy postmenopausal overweight or obese women were randomized to either PD (n=35) or NNR diet (n=35). Dietary iodine intake, 24-UIC, 24-h urinary iodine excretion (24-UIE), free thyroxin (FT4), free triiodothyronine (FT3) and thyrotropin (TSH) were measured at baseline, 6 and 24 months. Completeness of urine sampling was monitored by para-aminobenzoic acid and salt intake by urinary sodium.
resultsAt baseline, median 24-UIC (71.0 μg/l) and 24-UIE (134.0 μg/d) were similar in the PD and NNR groups. After 6 months, 24-UIC had decreased to 36.0 μg/l (P=0.001) and 24-UIE to 77.0 μg/d (P=0.001) in the PD group; in the NNR group, levels were unaltered. FT4, TSH and FT3 were similar in both groups, except for FT3 at 6 months being lower in PD than in NNR group.
conclusionsA PD results in a higher risk of developing ID, than a diet according to the NNR. Therefore, we suggest iodine supplementation should be considered when on a PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.