ArticleeLife2017
Causal evidence for lateral prefrontal cortex dynamics supporting cognitive control.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Hierarchical Reconfiguration of Neurocognitive Task Set Representations Mediates Cognitive Flexibility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.bioRxiv : the preprint server for biology · 2026Article
- Integrated Representations of Threat and Controllability in the Lateral Frontal Pole.Journal of cognitive neuroscience · 2026Article
- Hierarchical Reconfiguration of Neurocognitive Task Set Representations Mediates Cognitive Flexibility.bioRxiv : the preprint server for biology · 2026Article
- Functional and effective connectivity alterations relate to cognitive performance in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.Brain communications · 2026Article
- Old-New Recognition Memory Revisited.bioRxiv : the preprint server for biology · 2025Article
- Multimodal neuroimaging data boosts the prediction of multifaceted cognition.Research square · 2025Article
- Complex functions of human lateral frontopolar cortex.Brain : a journal of neurology · 2025Review
- Flexible Reconfigurations of Brain Networks During Decisions With Predefined Versus Self-Generated Options.Human brain mapping · 2025Article
- Preparatory attentional templates in prefrontal and sensory cortex encode target-associated information.eLife · 2025Article
- Reciprocal Predictions Between Reading Achievement and Cognitive Flexibility Development in Children and the Mediating Roles of the Left Middle Frontal Gyrus.Human brain mapping · 2025Article
- Narcissistic and Antisocial Personality Traits Are Both Encoded in the Triple Network: Connectomics Evidence.Psychophysiology · 2025Article
- Near-random connections support top-down feature-based attentional modulations in early sensory cortex.PLoS computational biology · 2025Article
- Encoding of visual stimuli and behavioral goals in distinct anatomical areas of monkey ventrolateral prefrontal cortex.PLoS biology · 2025Article
- An Exploratory Comparison of Alpha and Beta Network Connectivity Across Four Depression Subtypes.Journal of clinical medicine · 2025Article
- An fMRI dataset for investigating language control and cognitive control in bilinguals.Scientific data · 2025Article
- Using precision approaches to improve brain-behavior prediction.Trends in cognitive sciences · 2025Review
- Cognitive Control.Annual review of psychology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The lateral prefrontal cortex (LPFC) is essential for higher-level cognition, but the nature of its interactions in supporting cognitive control remains elusive. Previously (Nee and D'Esposito, 2016), dynamic causal modeling (DCM) indicated that mid LPFC integrates abstract, rostral and concrete, caudal influences to inform context-appropriate action. Here, we use continuous theta-burst transcranial magnetic stimulation (cTBS) to test this model causally. cTBS was applied to three LPFC sites and a control site in counterbalanced sessions. Behavioral modulations resulting from cTBS were largely predicted by information flow within the previously estimated DCM. However, cTBS to caudal LPFC unexpectedly impaired processes that are presumed to involve rostral LPFC. Adding a pathway from caudal to mid-rostral LPFC significantly improved the model fit and accounted for the observed behavioral findings. These data provide causal evidence for LPFC dynamics supporting cognitive control and demonstrate the utility of combining DCM with causal manipulations to test and refine models of cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.