Evidence map›Paper›PMID 28901150›Full record

ArticleOrganic letters2017

Function-Oriented Studies Targeting Pectenotoxin 2: Synthesis of the GH-Ring System and a Structurally Simplified Macrolactone.

Natasha F O'Rourke, Mu A, Henry N Higgs, Alan Eastman, Glenn C Micalizio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natasha F O'RourkeDepartment of Chemistry, Dartmouth College, Burke Laboratory , Hanover, New Hampshire 03755, United States.
Mu AGeisel School of Medicine, Dartmouth College , Hanover, New Hampshire 03755, United States.
Henry N HiggsGeisel School of Medicine, Dartmouth College , Hanover, New Hampshire 03755, United States.
Alan EastmanGeisel School of Medicine, Dartmouth College , Hanover, New Hampshire 03755, United States.
Glenn C MicalizioDepartment of Chemistry, Dartmouth College, Burke Laboratory , Hanover, New Hampshire 03755, United States.ORCID 0000-0002-3408-5570

Funding

Stereoselective Synthesis via Metallacycle-Mediated Bond ConstructionR01GM080266 · NIGMS · YALE UNIVERSITY · PI MICALIZIO, GLENN C · 2007 to 2019
$4.8M
NIGMS NIH HHS R01 GM080266
6 · The paper itself

Abstract

A chemical foundation for function-oriented studies of pectenotoxin 2 (PTX2) is described. A synthesis of the bicyclic GH-system, and the design and synthesis of a PTX2-analogue, is presented. While maintaining critical features for actin binding, and lacking the Achilles' heel for the natural product's anticancer activity (the AB-spiroketal), this first-generation analogue did not possess the anticancer properties of PTX2, an observation that indicates the molecular significance of features present in the natural product's CDEF-tetracycle.

Indexed as

FuransMacrolidesMolecular StructurePolyether ToxinsPyransFuransMacrolidespectenotoxin 2Polyether ToxinsPyrans

Identifiers

PMID28901150
PMCPMC5633828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.