Evidence map›Paper›PMID 28900926›Full record

ReviewAdvances in experimental medicine and biology2017

Immunological Disorders: Regulation of Ca

Sonal Srikanth, Jin Seok Woo, Zuoming Sun, Yousang Gwack

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Inborn Errors of Immunity and Cytokine Storm Syndromes.Advances in experimental medicine and biology · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Altered CaInternational journal of molecular sciences · 2020
    Review
  13. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020
    Article
  14. Article
  15. Immunosuppressive Activity ofFrontiers in pharmacology · 2020
    Article
  16. Article
  17. Calcium signalling in T cells.Nature reviews. Immunology · 2019
    Review
  18. The CaNature immunology · 2019
    Article
  19. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.Journal of immunology (Baltimore, Md. : 1950) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sonal SrikanthDepartment of Physiology, David Geffen School of Medicine at UCLA, 53-266 CHS, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA.
Jin Seok WooDepartment of Physiology, David Geffen School of Medicine at UCLA, 53-266 CHS, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA.
Zuoming SunDepartment of Molecular Immunology, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Yousang GwackDepartment of Physiology, David Geffen School of Medicine at UCLA, 53-266 CHS, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. ygwack@mednet.ucla.edu.
University of California, Los Angeles · USCity of Hope · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Novel regulators of store-operated Ca2+ entry in immune systemsR01AI083432 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2009 to 2020
$3.8M
The function of CRAC channels in airway inflammationR21AI109059 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AKBARI, OMID, GWACK, YOUSANG · 2016 to 2017
$445k
Distinct functions of Orai1 and Orai2 in naive and effector helper T cellsR21AI130653 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SRIKANTH, SONAL · 2017 to 2018
$424k
NCI NIH HHS P30 CA033572NIAID NIH HHS R01 AI083432NIAID NIH HHS R21 AI109059NIAID NIH HHS R21 AI130653NIH HHS AI-083432NIH HHS AI109059
6 · The paper itself

Abstract

Engagement of T cell receptors (TCRs) with cognate antigens triggers cascades of signaling pathways in helper T cells. TCR signaling is essential for the effector function of helper T cells including proliferation, differentiation, and cytokine production. It also modulates effector T cell fate by inducing cell death, anergy (nonresponsiveness), exhaustion, and generation of regulatory T cells. One of the main axes of TCR signaling is the Ca

Indexed as

AnimalsCalciumCalcium ChannelsCalcium SignalingHumansImmune System DiseasesReceptors, Antigen, T-CellStromal Interaction MoleculesT-LymphocytesCalciumCalcium ChannelsReceptors, Antigen, T-CellStromal Interaction MoleculesCRAC channelsCytokine productionDifferentiation of T cellsEffector T cellsOrai and STIM proteinsT-cell receptor signaling

Identifiers

PMID28900926
PMCPMC8957800
OpenAlexW2755287478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.