Evidence map›Paper›PMID 28900831›Full record

ArticleMolecular imaging and biology2018

[

Kyle Kuszpit, Bradley S Hollidge, Xiankun Zeng, Robert G Stafford, Sharon Daye, Xiang Zhang, Falguni Basuli, Joseph W Golden, Rolf E Swenson, Darci R Smith and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2022
    Article
  6. Article
  7. Article
  8. Cellular sources of TSPO expression in healthy and diseased brain.European journal of nuclear medicine and molecular imaging · 2021
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Frontiers in cellular and infection microbiology · 2019
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kyle KuszpitMolecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425, Porter St., Ft. Detrick, Frederick, MD, 21702, USA.
Bradley S HollidgeVirology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425, Porter St., Ft. Detrick, Frederick, MD, 21702, USA.
Xiankun ZengPathology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425, Porter St., Ft. Detrick, Frederick, MD, 21702, USA.
Robert G StaffordMolecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425, Porter St., Ft. Detrick, Frederick, MD, 21702, USA.
Sharon DayePathology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425, Porter St., Ft. Detrick, Frederick, MD, 21702, USA.
Xiang ZhangImaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 9800 Medical Center Drive, Bldg. B., #2034, Bethesda, MD, 20892, USA.
Falguni BasuliImaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 9800 Medical Center Drive, Bldg. B., #2034, Bethesda, MD, 20892, USA.
Joseph W GoldenVirology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425, Porter St., Ft. Detrick, Frederick, MD, 21702, USA.
Rolf E SwensonImaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 9800 Medical Center Drive, Bldg. B., #2034, Bethesda, MD, 20892, USA.
Darci R SmithVirology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425, Porter St., Ft. Detrick, Frederick, MD, 21702, USA. darci.r.smith.ctr@mail.mil.
Thomas M BocanMolecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425, Porter St., Ft. Detrick, Frederick, MD, 21702, USA. thomas.m.bocan.ctr@mail.mil.
United States Army Medical Research Institute of Infectious Diseases · USNational Institutes of Health · USNational Heart Lung and Blood Institute · US

Funding

Imaging Probe Development CenterZICHL005090 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SWENSON, ROLF · 2011 to 2025
$22.2M
Defense Advanced Research Projects Agency 15094637
6 · The paper itself

Abstract

purposeThe association of Zika virus (ZIKV) infection and development of neurological sequelae require a better understanding of the pathogenic mechanisms causing severe disease. The purpose of this study was to evaluate the ability and sensitivity of positron emission tomography (PET) imaging using [ PROCEDURES: We assessed ZIKV-induced pathogenesis in wild-type C57BL/6 mice administered an antibody to inhibit type I interferon (IFN) signaling. [

resultsIn susceptible ZIKV-infected mice, viral titers in the brain increased from days 3 to 10 PI. Over this span, these mice showed a two- to sixfold increase in global brain neuroinflammation using [

conclusionsThe results of the current study demonstrate that global neuroinflammation plays a significant role in the progression of ZIKV infection and that [

Indexed as

Positron-Emission TomographyAnimalsBrainFemaleFluorine RadioisotopesGliosisInflammationMice, Inbred C57BLPyrazolesPyrimidinesReceptor, Interferon alpha-betaRNA, ViralZika VirusZika Virus InfectionFluorine RadioisotopesIfnar1 protein, mouseN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamidePyrazolesPyrimidinesReceptor, Interferon alpha-betaRNA, ViralAnimal modelDPA-714MiceNeuroinflammationPathologyPET imagingTherapeuticsTSPOZika virus

Identifiers

PMID28900831
PMCPMC5862915
OpenAlexW2755850531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.