Evidence map›Paper›PMID 28900822›Full record

SynthesisJournal of cancer survivorship : research and practice2018

An international review and meta-analysis of prehabilitation compared to usual care for cancer patients.

C Treanor, T Kyaw, M Donnelly

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of cancer survivorship : research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03500393 (A Remotely Supervised Exercise Program for Lung Cancer Patients Undergoing Chemoradiation), which is not on this map. Cited by 62 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03500393 naterminatednot on this map

A Remotely Supervised Exercise Program for Lung Cancer Patients Undergoing Chemoradiation

TypeinterventionalSponsorDartmouth-Hitchcock Medical CenterRan2018 to 2021Enrolled4ConditionsLung CancerArmsRemotely Supervised Exercise (REM), Unsupervised Exercise (UNSUP)
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Physical prehabilitation in patients with breast cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. High-intensity interval training in the prehabilitation of cancer patients-a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  6. Pooled it
  7. A Systematic Review and Meta-analysis of Physical Exercise Prehabilitation in Major Abdominal Surgery (PROSPERO 2017 CRD42017080366).Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Pooled it
  8. Trial
  9. Trial
  10. Lessons learned from a pilot randomized clinical trial of home-based exercise prescription before allogeneic hematopoietic cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Trial
  11. Trial
  12. Review
  13. Review
  14. Observational
  15. Prehabilitation beyond the trimodal standard: occupational therapy in a quadrimodal cancer care model.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

C TreanorCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Institute of Clinical Sciences-B Building, Royal Victoria Hospital Site, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK. c.treanor@qub.ac.uk.ORCID 0000-0002-3209-8060
T KyawCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Institute of Clinical Sciences-B Building, Royal Victoria Hospital Site, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK.
M DonnellyCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Institute of Clinical Sciences-B Building, Royal Victoria Hospital Site, Queen's University Belfast, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK.

Funding

Medical Research Council MR/K023241/1
6 · The paper itself

Abstract

purposeThe purpose of the study is to systematically review and synthesise randomised controlled trials investigating the effectiveness of prehabilitation compared to usual care for newly diagnosed, adult-onset cancer patients.

methodsMEDLINE, EMBASE, PsycINFO, CINAHL and SSCI were searched up to April 2017. Studies were included if disease-related, treatment-related, patient-reported and health service utilisation outcomes were assessed. Two reviewers independently reviewed and appraised the risk of bias of each study.

resultsEighteen studies were included. Interventions comprised one or more of the following components: psychological support, education and exercise. Meta-analyses found that pelvic floor muscle training (PFMT) significantly increased odds of continence at 3 months (OR = 3.29, 95% CI = 1.57-6.91), but did not significantly reduce daily pad use at 6 months post-surgery Mean Difference (MD)= ( = - 0.96, 95% CI = - 2.04-0.12) for prostate cancer patients. Although quality of life improved due to PFMT, functional ability or distress did not. Further meta-analyses indicated that pre-surgical exercise significantly reduced length of hospital stay (MD = - 4.18, 95% CI = - 5.43-- 2.93) and significantly lowered odds of post-surgery complications (OR = 0.25, 95% CI = 0.10-0.66) for lung cancer patients. Psychology-based prehabilitation significantly improved mood, physical well-being and immune function for prostate cancer patients and improved fatigue and psychological outcomes and a trend for better quality of life among breast cancer patients. Risk of bias was high for most studies.

conclusionsPrehabilitation appears to benefit cancer patients. Rigorous trials are needed to investigate the effectiveness of prehabilitation among other cancer sites and other related effects. The cost-effectiveness of prehabilitation remains unanswered. IMPLICATIONS FOR CANCER SURVIVORS: Providing interventions earlier in the care pathway may lead to better outcomes for patients during survivorship.

Indexed as

FemaleHumansMaleNeoplasmsQuality of LifeSurvivorsCancerMeta-analysisPrehabilitationSystematic review

Identifiers

PMID28900822

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.