Evidence map›Paper›PMID 28900772›Full record

ArticleMolecular and cellular biochemistry2018

Clathrin-dependent internalization, signaling, and metabolic processing of guanylyl cyclase/natriuretic peptide receptor-A.

Naveen K Somanna, Indra Mani, Satyabha Tripathi, Kailash N Pandey

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Naveen K SomannaDepartment of Physiology, SL-39, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Indra ManiDepartment of Physiology, SL-39, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Satyabha TripathiDepartment of Physiology, SL-39, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Kailash N PandeyDepartment of Physiology, SL-39, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA. kpandey@tulane.edu.
Tulane University · US

Funding

Study of ANP Receptor:Gene Targeting and ExpressionR01HL062147 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1998 to 2020
$5.0M
ANP RECEPTOR--MOLECULAR APPROACH OF SIGNALING MECHANISMSR01HL057531 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1997 to 2013
$2.5M
ANP Receptor: Molecular approach of signaling mechanismsR56HL057531 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 2009 to 2009
$373k
National Heart, Lung, and Blood Institute HL057531National Heart, Lung, and Blood Institute HL062147NHLBI NIH HHS R01 HL057531NHLBI NIH HHS R01 HL062147NHLBI NIH HHS R56 HL057531
6 · The paper itself

Abstract

Cardiac hormones, atrial and brain natriuretic peptides (ANP and BNP), have pivotal roles in renal hemodynamics, neuroendocrine signaling, blood pressure regulation, and cardiovascular homeostasis. Binding of ANP and BNP to the guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) induces rapid internalization and trafficking of the receptor via endolysosomal compartments, with concurrent generation of cGMP. However, the mechanisms of the endocytotic processes of NPRA are not well understood. The present study, using

Indexed as

Atrial Natriuretic FactorClathrinEndocytosisGuanylate CyclaseHEK293 CellsHumansProtein TransportReceptors, Atrial Natriuretic FactorSecond Messenger SystemsAtrial Natriuretic Factoratrial natriuretic factor receptor AClathrinGuanylate CyclaseReceptors, Atrial Natriuretic FactorClathrin-coated pitDynaminEndocytosisGuanylyl cyclase/natriuretic peptide receptor-ARecombinant HEK-293 cells

Identifiers

PMID28900772
PMCPMC6542269
OpenAlexW2756140677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.