ArticleInternational journal of biometeorology2017
Transcriptome analysis and identification of significantly differentially expressed genes in Holstein calves subjected to severe thermal stress.
Article in International journal of biometeorology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
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- Comparative transcriptomic analysis reveals the important role of hepatic fatty acid metabolism in the acute heat stress response in chickens.BMC genomics · 2025Article
- Differential gene expression analysis using RNA-seq in the blood of goats exposed to transportation stress.Scientific reports · 2023Article
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- Liver Transcriptome Response to Heat Stress in Beijing You Chickens and Guang Ming Broilers.Genes · 2022Article
- Improving Genomic Selection for Heat Tolerance in Dairy Cattle: Current Opportunities and Future Directions.Frontiers in genetics · 2022Review
- Heat stress and immune response phenotype affect DNA methylation in blood mononuclear cells from Holstein dairy cows.Scientific reports · 2021Article
- Genome-wide identification and functional prediction of long non-coding RNAs in Sprague-Dawley rats during heat stress.BMC genomics · 2021Article
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- Prediction models, assessment methodologies and biotechnological tools to quantify heat stress response in ruminant livestock.International journal of biometeorology · 2019Review
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- Identifying Hub Genes for Heat Tolerance in Water Buffalo (Frontiers in genetics · 2019Article
- Cardiac and Skeletal Muscle Transcriptome Response to Heat Stress in Kenyan Chicken Ecotypes Adapted to Low and High Altitudes Reveal Differences in Thermal Tolerance and Stress Response.Frontiers in genetics · 2019Article
- Tracking transcriptomic responses to endogenous and exogenous variation in cetaceans in the Southern California Bight.Conservation physiology · 2019Article
- Transcriptomic Analysis Reveals Insights on Male Infertility inFrontiers in physiology · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
RNA-Seq analysis was used to characterize transcriptome response of Holstein calves to thermal stress. A total of eight animals aged between 2 and 3 months were randomly selected and subjected to thermal stress corresponding to a temperature humidity index of 95 in an environmentally controlled house for 12 h consecutively for 3 days. A set of 15,787 unigenes were found to be expressed and after a threshold of threefold change, and a Q value <0.05; 502, 394, and 376 genes were found to be differentially expressed on days 1, 2, and 3 out of which 343, 261 and 256 genes were upregulated and 159, 133, and 120 genes were downregulated. Only 356 genes out of these were expressed on all 3 days, and only they were considered as significantly differentially expressed. KEGG pathway analysis revealed that ten pathways were significantly enriched; the top two among them were protein processing in endoplasmic reticulum and MAPK signaling pathways. These results suggest that thermal stress triggered a complex response in Holstein calves and the animals adjusted their physiological and metabolic processes to survive. Many of the genes identified in this study have not been previously reported to be involved in thermal stress response. The results of this study extend our understanding of the animal's response to thermal stress and some of the identified genes may prove useful in the efforts to breed Holstein cattle with superior thermotolerance, which might help in minimizing production loss due to thermal stress.
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