Evidence map›Paper›PMID 28900724›Full record

ArticleJournal of neurology2017

Hypothalamic dysfunction is related to sleep impairment and CSF biomarkers in Alzheimer's disease.

Claudio Liguori, Agostino Chiaravalloti, Marzia Nuccetelli, Francesca Izzi, Giuseppe Sancesario, Andrea Cimini, Sergio Bernardini, Orazio Schillaci, Nicola Biagio Mercuri, Placidi Fabio

Abstract read
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In one paragraph

Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  10. Cerebrospinal-fluid Orexin-A levels in different neurocognitive disorders: a comparison study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  11. Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Claudio LiguoriSleep Medicine Centre, Neurophysiopathology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy. dott.claudioliguori@yahoo.it.
Agostino ChiaravallotiDepartment of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy.
Marzia NuccetelliClinical Biochemistry and Molecular Biology, University of Rome "Tor Vergata", Rome, Italy.
Francesca IzziSleep Medicine Centre, Neurophysiopathology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Giuseppe SancesarioNeurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Andrea CiminiDepartment of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy.
Sergio BernardiniClinical Biochemistry and Molecular Biology, University of Rome "Tor Vergata", Rome, Italy.
Orazio SchillaciDepartment of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy.
Nicola Biagio MercuriSleep Medicine Centre, Neurophysiopathology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Placidi FabioSleep Medicine Centre, Neurophysiopathology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
University of Rome Tor Vergata · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothalamus is a key brain region regulating several essential homeostatic functions, including the sleep-wake cycle. Alzheimer's disease (AD) pathology affects nuclei controlling sleep-wake rhythm sited in this brain area. Since only post-mortem studies documented the relationship between hypothalamic atrophy and sleep-wake cycle impairment, we investigated in AD patients the possible hypothalamic in vivo alteration using 2-deoxy-2-(18F) fluoro-D-glucose ([18F]FDG) positron emission tomography ([18F]FDG PET), and its correlations with sleep impairment and cerebrospinal-fluid (CSF) AD biomarkers (tau proteins and β-amyloid

Indexed as

Alzheimer DiseaseAgedAmyloid beta-PeptidesFemaleFluorodeoxyglucose F18HumansHypothalamusImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMental Status SchedulePeptide FragmentsPolysomnographyPositron-Emission TomographySleep Wake Disorderstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)Fluorodeoxyglucose F18Peptide Fragmentstau Proteins[18F]FDG PETAlzheimer’s disease CSF biomarkersHypothalamusOrexinPolysomnographyREM sleep

Identifiers

PMID28900724
OpenAlexW2755755000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.