ArticleChemical communications (Cambridge, England)2017
A mutation-resistant deoxyribozyme OR gate for highly selective detection of viral nucleic acids.
Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Catalyst-based biomolecular logic gates.Catalysts (Basel, Switzerland) · 2022Article
- Construction of Multiple Logic Circuits Based on Allosteric DNAzymes.Biomolecules · 2022Article
- DNA circuits driven by conformational changes in DNAzyme recognition arms.RSC advances · 2020Article
- FaptaSyme: A Strategy for Converting a Monomer/Oligomer-Nonselective Aptameric Sensor into an Oligomer-Selective One.Chembiochem : a European journal of chemical biology · 2018Article
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Authors and funding
8 authors at 3 institutions in 5 countries.
Funding
Abstract
Highly selective probes hybridize only to fully complementary DNA or RNA sequences and, therefore, often fail to recognize mutated viral genomes. Here we designed a probe that possesses two seemingly incompatible properties: it tolerates some point mutations in genome, while it remains selective towards others. An OR deoxyribozyme logic gate was designed to fluorescently report the sequences of enterovirus 71 (EV71) covering ∼90% of all known EV71 strains. Importantly, sequences of closely related coxsackieviruses that differed by single nucleotides were reliably differentiated in 7 out of 8 cases.
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Registered trials
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