Evidence map›Paper›PMID 28900244›Full record

ArticleScientific reports2017

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

Ruth E Mitchell, Masriana Hassan, Bronwen R Burton, Graham Britton, Elaine V Hill, Johan Verhagen, David C Wraith

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Peripheral Blood Immune Cell Composition After Autologous MSC Infusion in Kidney Transplantation Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2023
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  7. Review
  8. Review
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  10. Therapeutic effect of baicalein as an antiparasitic agent againstJournal of Zhejiang University. Science. B · 2025
    Article
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  12. Article
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  14. Article
  15. Review
  16. Article
  17. Vitamin D affects antiphospholipid syndrome by regulating T cells (Review).International journal of molecular medicine · 2025
    Review
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ruth E MitchellSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Masriana HassanSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Bronwen R BurtonSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Graham BrittonSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Elaine V HillSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Johan VerhagenSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
David C WraithSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom. d.wraith@bham.ac.uk.ORCID 0000-0003-2147-5614
University of Bristol · GBKing's College London · GBUniversiti Putra Malaysia · MY

Funding

Wellcome Trust
6 · The paper itself

Abstract

IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4

Indexed as

AnimalsBiomarkersCytokinesImmunophenotypingInterleukin-10Interleukin-4Interleukin-4 Receptor alpha SubunitLymphocyte ActivationMiceMice, KnockoutPhenotypeReceptors, Cell SurfaceSTAT6 Transcription FactorTh1 CellsTh2 CellsBiomarkersCytokinesIl4ra protein, mouseInterleukin-10Interleukin-4Interleukin-4 Receptor alpha SubunitReceptors, Cell SurfaceSTAT6 Transcription Factor

Identifiers

PMID28900244
PMCPMC5595963
OpenAlexW2750663813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.