ArticleScientific reports2017
Copine-7 binds to the cell surface receptor, nucleolin, and regulates ciliogenesis and Dspp expression during odontoblast differentiation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- First-In-Human Study of Safety, Tolerability, Efficacy, and Pharmacokinetics of CPNE7-Derived Peptide (Selcopintide) for Dentin Hypersensitivity.Clinical and translational science · 2025Trial
- The Interplay of Immune Response and Dental Enamel Formation in Health and Sickness.Advances in experimental medicine and biology · 2026Review
- Review
- Article
- Article
- Transcriptomic analyses of NeuroD1-mediated astrocyte-to-neuron conversion.Developmental neurobiology · 2022Article
- Upregulation of CPNE7 in mesenchymal stromal cells promotes oral squamous cell carcinoma metastasis through the NF-κB pathway.Cell death discovery · 2021Article
- High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma.Cancer biomarkers : section A of Disease markers · 2021Article
- CPNE7-Induced Autophagy Restores the Physiological Function of Mature Odontoblasts.Frontiers in cell and developmental biology · 2021Article
- Functions of Vertebrate Ferlins.Cells · 2020Review
- Expression of CPNE7 during mouse dentinogenesis.Journal of molecular histology · 2019Article
- Cell polarization: From epithelial cells to odontoblasts.European journal of cell biology · 2019Review
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tooth development is a progressive process regulated by interactions between epithelial and mesenchymal tissues. Our previous studies showed that copine-7 (Cpne7), a dental epithelium-derived protein, is a signalling molecule that is secreted by preameloblasts and regulates the differentiation of preodontoblasts into odontoblasts. However, the mechanisms involved in the translocation of Cpne7 from preameloblasts to preodontoblasts and the functions of Cpne7 during odontogenesis are poorly understood. Here, we showed that the internalization of Cpne7 was mediated primarily by caveolae. This process was initiated by Cpne7 binding to the cell surface protein, nucleolin. Treatment with recombinant Cpne7 protein (rCpne7) in human dental pulp cells (hDPCs) caused an increase in the number of ciliated cells. The expression level of cilium components, Ift88 and Kif3a, and Dspp were increased by rCpne7. Treatment with Ift88 siRNA in hDPCs and MDPC-23 cells significantly down-regulated the expression of Dspp, an odontoblastic differentiation marker gene. Furthermore, the treatment with nucleolin siRNA in MDPC-23 cells decreased the expression of Dmp1, Dspp, and cilium components. Our findings suggested that the binding of Cpne7 with its receptor, nucleolin, has an important function involving Cpne7 internalization into preodontoblasts and regulation of Dspp expression through ciliogenesis during odontoblast differentiation.
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