ArticleScientific reports2017
Iron oxide nanoparticles can cross plasma membranes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review.Journal of nanobiotechnology · 2023Pooled it
- Article
- Unveiling the role of inorganic nanoparticles in Earth's biochemical evolution through electron transfer dynamics.iScience · 2024Review
- Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology.Frontiers in chemistry · 2024Review
- Innovative unified impact of magnetite iron nanoparticles and quercetin on broiler chickens: performance, antioxidant and immune defense and controlling ofFrontiers in veterinary science · 2024Article
- Nanoparticle-based approaches for treating restenosis after vascular injury.Frontiers in pharmacology · 2024Review
- The Beneficial Effects of Static Magnetic Field and Iron Oxide Nanoparticles on the Vitrification of Mature Mice Oocytes.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- The "www" ofMembranes · 2022Review
- Intestinal and hepatic effects of iron oxide nanoparticles.Archives of toxicology · 2021Article
- Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes.Nanomaterials (Basel, Switzerland) · 2019Review
- On the mechanism of the electrophysiological changes and membrane lesions induced by asbestos fiber exposure in Xenopus laevis oocytes.Scientific reports · 2019Article
- Magnetic Nanoparticles in Human Cervical Skin.Frontiers in medicine · 2019Article
- Hide and Seek: Nanomaterial Interactions With the Immune System.Frontiers in immunology · 2019Review
- Magnetomotive Displacement of the Tympanic Membrane Using Magnetic Nanoparticles: Toward Enhancement of Sound Perception.IEEE transactions on bio-medical engineering · 2018Article
- The Detailed Bactericidal Process of Ferric Oxide Nanoparticles on E. coli.Molecules (Basel, Switzerland) · 2018Article
- Magnetic Nanoconjugated Teicoplanin: A Novel Tool for Bacterial Infection Site Targeting.Frontiers in microbiology · 2018Article
- Iron oxide nanozyme suppresses intracellularTheranostics · 2018Article
- Modern iron replacement therapy: clinical and pathophysiological insights.International journal of hematology · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Iron deficiency is a major global public health problem despite decades of efforts with iron supplementation and fortification. The issue lies on the poor tolerability of the standard of care soluble iron salts, leading to non-compliance and ineffective correction of iron-deficiency anaemia. Iron nanoformulations have been proposed to fortify food and feed to address these issues. Since it was just postulated that some nanoparticles (NPs) might cross the plasma membrane also by a non-endocytotic pathway gaining direct access to the cytoplasm, we have studied iron NP uptake under this perspective. To this aim, we have used a recently tested protocol that has proven to be capable of following the cytoplasmic changes of iron concentration dynamics and we have demonstrated that iron oxide NPs, but not zerovalent iron NPs nor iron oxide NPs that were surrounded by a protein corona, can cross plasma membranes. By electrophysiology, we have also shown that a small and transient increase of membrane conductance parallels NP crossing of plasma membrane.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.